A conserved motif within the NSP2 of SARS-CoV-2 is required for processing of the distal NSP1/NSP2 junction by NSP3

A conserved motif within the NSP2 of SARS-CoV-2 is required for processing of the distal NSP1/NSP2 junction by NSP3

Abstract In 2019, the severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2) started to spread globally and caused the COVID-19 pandemic. SARS-CoV-2, like other members of the Coronaviridae, has a single-stranded, positive sense RNA genome about 30 kb in length, which is translated to ge...

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Bibliographic Details
Main Authors: Thea Kristensen, Preben Normann, Graham J. Belsham
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
SARS-CoV-2
Intramolecular chaperone
Coronavirus
NSP2
Proteolytic processing
Online Access:https://doi.org/10.1038/s41598-025-10244-2
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https://doi.org/10.1038/s41598-025-10244-2

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