Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model
This study investigated the effects of activation and inhibition of the PI3K/AKT and TLR-4/NF-κB signaling pathways on insulin resistance in a high-fat diet-induced obese rat model. The results indicate that a high-fat diet can activate these signaling pathways by regulating the expression of relate...
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| Format: | Article |
| Language: | English |
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De Gruyter
2024-12-01
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| Series: | Open Life Sciences |
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| Online Access: | https://doi.org/10.1515/biol-2022-1014 |
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| _version_ | 1841556506293567488 |
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| author | Song Liya Li Lihua |
| author_facet | Song Liya Li Lihua |
| author_sort | Song Liya |
| collection | DOAJ |
| description | This study investigated the effects of activation and inhibition of the PI3K/AKT and TLR-4/NF-κB signaling pathways on insulin resistance in a high-fat diet-induced obese rat model. The results indicate that a high-fat diet can activate these signaling pathways by regulating the expression of related proteins, affecting metabolic health. Rat PI3K/AKT pathway protein. |
| format | Article |
| id | doaj-art-7d247e0acfe7428694e97dc949ffff35 |
| institution | Kabale University |
| issn | 2391-5412 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj-art-7d247e0acfe7428694e97dc949ffff352025-01-07T07:55:32ZengDe GruyterOpen Life Sciences2391-54122024-12-01191389891810.1515/biol-2022-1014Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat modelSong Liya0Li Lihua1Department of Children’s Center, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing, 101149, ChinaDepartment of Children’s Center, Beijing Luhe Hospital Affiliated to Capital Medical University, Beijing, 101149, ChinaThis study investigated the effects of activation and inhibition of the PI3K/AKT and TLR-4/NF-κB signaling pathways on insulin resistance in a high-fat diet-induced obese rat model. The results indicate that a high-fat diet can activate these signaling pathways by regulating the expression of related proteins, affecting metabolic health. Rat PI3K/AKT pathway protein.https://doi.org/10.1515/biol-2022-1014obesity rat modelhigh-fat dietphosphatidylinositol-3-kinase/protein kinase btoll-like receptor/nuclear factor kappa bdifferencesexpression |
| spellingShingle | Song Liya Li Lihua Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model Open Life Sciences obesity rat model high-fat diet phosphatidylinositol-3-kinase/protein kinase b toll-like receptor/nuclear factor kappa b differences expression |
| title | Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model |
| title_full | Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model |
| title_fullStr | Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model |
| title_full_unstemmed | Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model |
| title_short | Differential expression of phosphoinositide 3-kinase/protein kinase B and Toll-like receptor/nuclear factor kappa B signaling pathways in experimental obesity Wistar rat model |
| title_sort | differential expression of phosphoinositide 3 kinase protein kinase b and toll like receptor nuclear factor kappa b signaling pathways in experimental obesity wistar rat model |
| topic | obesity rat model high-fat diet phosphatidylinositol-3-kinase/protein kinase b toll-like receptor/nuclear factor kappa b differences expression |
| url | https://doi.org/10.1515/biol-2022-1014 |
| work_keys_str_mv | AT songliya differentialexpressionofphosphoinositide3kinaseproteinkinasebandtolllikereceptornuclearfactorkappabsignalingpathwaysinexperimentalobesitywistarratmodel AT lilihua differentialexpressionofphosphoinositide3kinaseproteinkinasebandtolllikereceptornuclearfactorkappabsignalingpathwaysinexperimentalobesitywistarratmodel |