Lower Serum IL-10 Linked to Oral Manifestations in Diabetes Patients
Nanan Nur’aeny,1 Ahmedz Widiasta,2 Yessy Novianti,3 Dewi Zakiawati,1 Naninda Berliana Pratidina,4 Irna Sufiawati1 1Oral Medicine Department, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia; 2Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Dr Hasan Sadikin...
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Dove Medical Press
2025-01-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
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| author | Nur'aeny N Widiasta A Novianti Y Zakiawati D Pratidina NB Sufiawati I |
| author_facet | Nur'aeny N Widiasta A Novianti Y Zakiawati D Pratidina NB Sufiawati I |
| author_sort | Nur'aeny N |
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| description | Nanan Nur’aeny,1 Ahmedz Widiasta,2 Yessy Novianti,3 Dewi Zakiawati,1 Naninda Berliana Pratidina,4 Irna Sufiawati1 1Oral Medicine Department, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia; 2Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Dr Hasan Sadikin Hospital, Bandung, Indonesia; 3Oral Medicine Residency Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia; 4Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, IndonesiaCorrespondence: Nanan Nur’aeny, Oral Medicine Department, Faculty of Dentistry, Universitas Padjadjaran, Jalan Sekeloa Selatan I, Bandung, 40132, Indonesia, Tel +628112183008, Email nanan.nuraeny@unpad.ac.idBackground: Diabetes mellitus (DM) is a chronic disease that remains a global health problem with increasing prevalence, particularly in Indonesia. The presence of oral manifestations in patients with DM is influenced by changes in immune system function. Interleukin-10 (IL-10) is an inflammatory marker implicated in DM. However, no studies have investigated the differences in IL-10 levels between non-DM and DM patients with and without oral manifestations.Objective: This study aimed to compare the serum levels of IL-10 between non-DM and DM patients with and without oral manifestations at Dr. Hasan Sadikin Hospital Bandung.Methodology: This observational study used a cross-sectional design. A total of 88 serum samples that met the inclusion criteria were selected, consisting of 37 (42%) samples from non-DM patients, 35 (39.8%) samples from DM patients with oral manifestations, and 16 (18.2%) samples from DM patients without oral manifestations. Serum levels of IL-10 were measured using an enzyme-linked immunosorbent assay (ELISA) kit.Results: Among the 35 DM patients with oral manifestations, xerostomia was the most common (80%). The mean serum IL-10 level was 0.93 pg/mL in non-DM patients, 0.80 pg/mL in DM patients with oral manifestations, and 1.08 pg/mL in DM patients without oral manifestations. Statistical analysis using the Kruskal–Wallis test showed a p-value of 0.008 (p ≤ 0.05), indicating a significant difference in serum levels of IL-10 between non-DM and DM patients with and without oral manifestations.Conclusion: DM patients with oral manifestations had lower IL-10 serum levels compared to non-DM patients and DM patients without oral manifestations. These findings suggest that monitoring IL-10 levels could help identify diabetic patients at higher risk for oral complications.Keywords: diabetes mellitus, interleukin-10, oral manifestation, serum |
| format | Article |
| id | doaj-art-7d05faa000b14f309a6eccae822ea9b9 |
| institution | Kabale University |
| issn | 1178-7007 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
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| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj-art-7d05faa000b14f309a6eccae822ea9b92025-01-07T16:42:40ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072025-01-01Volume 18758399066Lower Serum IL-10 Linked to Oral Manifestations in Diabetes PatientsNur'aeny NWidiasta ANovianti YZakiawati DPratidina NBSufiawati INanan Nur’aeny,1 Ahmedz Widiasta,2 Yessy Novianti,3 Dewi Zakiawati,1 Naninda Berliana Pratidina,4 Irna Sufiawati1 1Oral Medicine Department, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia; 2Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Dr Hasan Sadikin Hospital, Bandung, Indonesia; 3Oral Medicine Residency Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia; 4Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, IndonesiaCorrespondence: Nanan Nur’aeny, Oral Medicine Department, Faculty of Dentistry, Universitas Padjadjaran, Jalan Sekeloa Selatan I, Bandung, 40132, Indonesia, Tel +628112183008, Email nanan.nuraeny@unpad.ac.idBackground: Diabetes mellitus (DM) is a chronic disease that remains a global health problem with increasing prevalence, particularly in Indonesia. The presence of oral manifestations in patients with DM is influenced by changes in immune system function. Interleukin-10 (IL-10) is an inflammatory marker implicated in DM. However, no studies have investigated the differences in IL-10 levels between non-DM and DM patients with and without oral manifestations.Objective: This study aimed to compare the serum levels of IL-10 between non-DM and DM patients with and without oral manifestations at Dr. Hasan Sadikin Hospital Bandung.Methodology: This observational study used a cross-sectional design. A total of 88 serum samples that met the inclusion criteria were selected, consisting of 37 (42%) samples from non-DM patients, 35 (39.8%) samples from DM patients with oral manifestations, and 16 (18.2%) samples from DM patients without oral manifestations. Serum levels of IL-10 were measured using an enzyme-linked immunosorbent assay (ELISA) kit.Results: Among the 35 DM patients with oral manifestations, xerostomia was the most common (80%). The mean serum IL-10 level was 0.93 pg/mL in non-DM patients, 0.80 pg/mL in DM patients with oral manifestations, and 1.08 pg/mL in DM patients without oral manifestations. Statistical analysis using the Kruskal–Wallis test showed a p-value of 0.008 (p ≤ 0.05), indicating a significant difference in serum levels of IL-10 between non-DM and DM patients with and without oral manifestations.Conclusion: DM patients with oral manifestations had lower IL-10 serum levels compared to non-DM patients and DM patients without oral manifestations. These findings suggest that monitoring IL-10 levels could help identify diabetic patients at higher risk for oral complications.Keywords: diabetes mellitus, interleukin-10, oral manifestation, serumhttps://www.dovepress.com/lower-serum-il-10-linked-to-oral-manifestations-in-diabetes-patients-peer-reviewed-fulltext-article-DMSOdiabetes mellitusinterleukin-10oral manifestationserum. |
| spellingShingle | Nur'aeny N Widiasta A Novianti Y Zakiawati D Pratidina NB Sufiawati I Lower Serum IL-10 Linked to Oral Manifestations in Diabetes Patients Diabetes, Metabolic Syndrome and Obesity diabetes mellitus interleukin-10 oral manifestation serum. |
| title | Lower Serum IL-10 Linked to Oral Manifestations in Diabetes Patients |
| title_full | Lower Serum IL-10 Linked to Oral Manifestations in Diabetes Patients |
| title_fullStr | Lower Serum IL-10 Linked to Oral Manifestations in Diabetes Patients |
| title_full_unstemmed | Lower Serum IL-10 Linked to Oral Manifestations in Diabetes Patients |
| title_short | Lower Serum IL-10 Linked to Oral Manifestations in Diabetes Patients |
| title_sort | lower serum il 10 linked to oral manifestations in diabetes patients |
| topic | diabetes mellitus interleukin-10 oral manifestation serum. |
| url | https://www.dovepress.com/lower-serum-il-10-linked-to-oral-manifestations-in-diabetes-patients-peer-reviewed-fulltext-article-DMSO |
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