Evaluation of Collagen Triple Helix Repeat Containing-1 protein in Postmenopausal Women with Osteoporosis
Background: The collagen triple helix repeat containing 1 (CTHRC1) protein has been connected to decreased levels of vitamin D and calcium, as well as obesity. This study aimed to investigate the relationship between CTHRC1 and osteoporosis in post-menopausal women and compare with healthy subjects...
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University of Baghdad/ Al-Kindy College of Medicine
2024-12-01
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| Series: | مجله كليه طب الكندي |
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| Online Access: | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1547 |
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| author | Isam Salman Noor Ulhuda Mohammed Rand Jalal Abd Al-Ghanny Baydaa Abed Samara mutar |
| author_facet | Isam Salman Noor Ulhuda Mohammed Rand Jalal Abd Al-Ghanny Baydaa Abed Samara mutar |
| author_sort | Isam Salman |
| collection | DOAJ |
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Background: The collagen triple helix repeat containing 1 (CTHRC1) protein has been connected to decreased levels of vitamin D and calcium, as well as obesity. This study aimed to investigate the relationship between CTHRC1 and osteoporosis in post-menopausal women and compare with healthy subjects.
Subjects and Methods: A cross-sectional study consisted of 86 women were enrolled in this study and divided into three groups based on the results of dual-energy densitometry (DXA): 30 women with osteoporosis, 30 women with osteopenia, and 26 healthy women. Data on demographic and clinical features and laboratory values of Calcium (Ca) and Vitamin D3 (V.D3) were recorded.
Results: Women with osteoporosis had significantly increased levels of CTHRC1 (P = 0.0001) compare to HS groups. The CTHRC1 showed negative correlation with Ca and V.D3 value at (r= -0.453, P=0.001 and r= -0.415, P= 0.022) respectively in osteopenia patients. CTHRC1 alone show excellent discrimination power (AUC= 0.9) in identifying women with osteoporosis.
Conclusions: Serum CTHRC1 is a valid biomarker that can distinguish women with osteoporosis from HS group with high accuracy. Low calcium and vitamin D levels in this age group may be linked to an increase in the CTHRC1 levels and this could make it a Therapeutic target in future studies.
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| format | Article |
| id | doaj-art-7cf6201e19b14f548ae541a9ebfc42f7 |
| institution | Kabale University |
| issn | 1810-9543 2521-4365 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University of Baghdad/ Al-Kindy College of Medicine |
| record_format | Article |
| series | مجله كليه طب الكندي |
| spelling | doaj-art-7cf6201e19b14f548ae541a9ebfc42f72024-12-05T04:19:29ZengUniversity of Baghdad/ Al-Kindy College of Medicineمجله كليه طب الكندي1810-95432521-43652024-12-0120310.47723/hr739z611473Evaluation of Collagen Triple Helix Repeat Containing-1 protein in Postmenopausal Women with OsteoporosisIsam Salman 0https://orcid.org/0000-0003-2813-3879Noor Ulhuda Mohammed1https://orcid.org/0000-0003-3549-1578Rand Jalal Abd Al-Ghanny2Baydaa Abed3https://orcid.org/0000-0002-8895-7901Samara mutar 4National Diabetes Center, Mustansiriyah, IraqiDepartment of Chemistry, College of Science for Women, University of Baghdad, Baghdad, IraqMinistry of Higher Education and Scientific Research.National Diabetes Center, Mustansiriyah, IraqiDepartment of Chemistry, College of Science for Women, University of Baghdad, Iraqi Background: The collagen triple helix repeat containing 1 (CTHRC1) protein has been connected to decreased levels of vitamin D and calcium, as well as obesity. This study aimed to investigate the relationship between CTHRC1 and osteoporosis in post-menopausal women and compare with healthy subjects. Subjects and Methods: A cross-sectional study consisted of 86 women were enrolled in this study and divided into three groups based on the results of dual-energy densitometry (DXA): 30 women with osteoporosis, 30 women with osteopenia, and 26 healthy women. Data on demographic and clinical features and laboratory values of Calcium (Ca) and Vitamin D3 (V.D3) were recorded. Results: Women with osteoporosis had significantly increased levels of CTHRC1 (P = 0.0001) compare to HS groups. The CTHRC1 showed negative correlation with Ca and V.D3 value at (r= -0.453, P=0.001 and r= -0.415, P= 0.022) respectively in osteopenia patients. CTHRC1 alone show excellent discrimination power (AUC= 0.9) in identifying women with osteoporosis. Conclusions: Serum CTHRC1 is a valid biomarker that can distinguish women with osteoporosis from HS group with high accuracy. Low calcium and vitamin D levels in this age group may be linked to an increase in the CTHRC1 levels and this could make it a Therapeutic target in future studies. https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1547Collagen triple helix repeating containing protein1CTHRC1DXAOsteopeniaOsteoporosis |
| spellingShingle | Isam Salman Noor Ulhuda Mohammed Rand Jalal Abd Al-Ghanny Baydaa Abed Samara mutar Evaluation of Collagen Triple Helix Repeat Containing-1 protein in Postmenopausal Women with Osteoporosis مجله كليه طب الكندي Collagen triple helix repeating containing protein1 CTHRC1 DXA Osteopenia Osteoporosis |
| title | Evaluation of Collagen Triple Helix Repeat Containing-1 protein in Postmenopausal Women with Osteoporosis |
| title_full | Evaluation of Collagen Triple Helix Repeat Containing-1 protein in Postmenopausal Women with Osteoporosis |
| title_fullStr | Evaluation of Collagen Triple Helix Repeat Containing-1 protein in Postmenopausal Women with Osteoporosis |
| title_full_unstemmed | Evaluation of Collagen Triple Helix Repeat Containing-1 protein in Postmenopausal Women with Osteoporosis |
| title_short | Evaluation of Collagen Triple Helix Repeat Containing-1 protein in Postmenopausal Women with Osteoporosis |
| title_sort | evaluation of collagen triple helix repeat containing 1 protein in postmenopausal women with osteoporosis |
| topic | Collagen triple helix repeating containing protein1 CTHRC1 DXA Osteopenia Osteoporosis |
| url | https://jkmc.uobaghdad.edu.iq/index.php/MEDICAL/article/view/1547 |
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