Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adults
Abstract Background Respiratory viruses are linked to cardiovascular complications. We aim to compare cardiovascular complications due to COVID-19, influenza and RSV. Methods We analyzed cross-sectional data from hospitalized children and young adults (≤ 20 years) from 2020 and 2021 using National I...
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BMC
2024-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04366-0 |
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| author | Sagya Khanal Bishes Khanal Fu-Sheng Chou Anita J. Moon-Grady Laxmi V. Ghimire |
| author_facet | Sagya Khanal Bishes Khanal Fu-Sheng Chou Anita J. Moon-Grady Laxmi V. Ghimire |
| author_sort | Sagya Khanal |
| collection | DOAJ |
| description | Abstract Background Respiratory viruses are linked to cardiovascular complications. We aim to compare cardiovascular complications due to COVID-19, influenza and RSV. Methods We analyzed cross-sectional data from hospitalized children and young adults (≤ 20 years) from 2020 and 2021 using National Inpatient Sample (NIS). We included individuals hospitalized for COVID-19, RSV, and influenza, and weighted data were used to compare cardiovascular complications. Results Of 212,655 respiratory virus admissions, 85,055 were from COVID-19, 103,185 were from RSV, and 24,415 were from influenza. Myocarditis was higher in COVID-19 [0.9%, n = 740] as compared to influenza [0.2%, n = 55] and RSV [0.1%, n = 65]. In the adjusted logistic regression, the odds of myocarditis was 61% lower in influenza [aOR = 0.39 (0.20–0.76), P = 0.006], and 85% lower in RSV [aOR = 0.15 (0.07–0.34) P < 0.001] as compared to COVID-19. Bradyarrhythmias/heart block was higher in COVID-19 [0.8%, n = 690] versus influenza [0.5%, n = 110] and RSV [0.2%, n = 205]. After adjusting for confounders for bradyarrhythmias/heart block, compared to COVID-19, the odds were 49% lower in RSV [aOR = 0.51 (0.33–0.80), P = 0.004] but no statistically significant difference in influenza [aOR = 0.79 (0.48–1.31), P = 0.374] was seen. Tachyarrhythmias, sudden cardiac arrest, and in-hospital mortality showed no differences after adjusting for covariates. Conclusion Individuals with COVID-19 infection are more likely to develop cardiovascular complications compared to influenza and RSV, highlighting the need for higher index of suspicion and prompt treatment, as well as steps to limit infection and transmission of this virus in children. |
| format | Article |
| id | doaj-art-7ce60de46c8d49b99c2341b15a0ebfa0 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-7ce60de46c8d49b99c2341b15a0ebfa02024-12-01T12:08:56ZengBMCBMC Cardiovascular Disorders1471-22612024-11-012411910.1186/s12872-024-04366-0Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adultsSagya Khanal0Bishes Khanal1Fu-Sheng Chou2Anita J. Moon-Grady3Laxmi V. Ghimire4Nepal Medical College and Teaching HospitalKathmandu Medical College and Teaching HospitalDepartment of Neonatal-Perinatal Medicine, Kaiser Permanente Riverside Medical CenterDivision of Pediatric Cardiology, UCSF Benioff Children’s Hospital, Department of Pediatrics, University of California, San FranciscoDivision of Pediatric Cardiology, Fresno Regional campus, University of CaliforniaAbstract Background Respiratory viruses are linked to cardiovascular complications. We aim to compare cardiovascular complications due to COVID-19, influenza and RSV. Methods We analyzed cross-sectional data from hospitalized children and young adults (≤ 20 years) from 2020 and 2021 using National Inpatient Sample (NIS). We included individuals hospitalized for COVID-19, RSV, and influenza, and weighted data were used to compare cardiovascular complications. Results Of 212,655 respiratory virus admissions, 85,055 were from COVID-19, 103,185 were from RSV, and 24,415 were from influenza. Myocarditis was higher in COVID-19 [0.9%, n = 740] as compared to influenza [0.2%, n = 55] and RSV [0.1%, n = 65]. In the adjusted logistic regression, the odds of myocarditis was 61% lower in influenza [aOR = 0.39 (0.20–0.76), P = 0.006], and 85% lower in RSV [aOR = 0.15 (0.07–0.34) P < 0.001] as compared to COVID-19. Bradyarrhythmias/heart block was higher in COVID-19 [0.8%, n = 690] versus influenza [0.5%, n = 110] and RSV [0.2%, n = 205]. After adjusting for confounders for bradyarrhythmias/heart block, compared to COVID-19, the odds were 49% lower in RSV [aOR = 0.51 (0.33–0.80), P = 0.004] but no statistically significant difference in influenza [aOR = 0.79 (0.48–1.31), P = 0.374] was seen. Tachyarrhythmias, sudden cardiac arrest, and in-hospital mortality showed no differences after adjusting for covariates. Conclusion Individuals with COVID-19 infection are more likely to develop cardiovascular complications compared to influenza and RSV, highlighting the need for higher index of suspicion and prompt treatment, as well as steps to limit infection and transmission of this virus in children.https://doi.org/10.1186/s12872-024-04366-0COVID-19Cardiovascular complicationsHospital outcomesInfluenzaMortalityRSV |
| spellingShingle | Sagya Khanal Bishes Khanal Fu-Sheng Chou Anita J. Moon-Grady Laxmi V. Ghimire Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adults BMC Cardiovascular Disorders COVID-19 Cardiovascular complications Hospital outcomes Influenza Mortality RSV |
| title | Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adults |
| title_full | Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adults |
| title_fullStr | Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adults |
| title_full_unstemmed | Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adults |
| title_short | Comparison of mortality and cardiovascular complications due to COVID-19, RSV, and influenza in hospitalized children and young adults |
| title_sort | comparison of mortality and cardiovascular complications due to covid 19 rsv and influenza in hospitalized children and young adults |
| topic | COVID-19 Cardiovascular complications Hospital outcomes Influenza Mortality RSV |
| url | https://doi.org/10.1186/s12872-024-04366-0 |
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