Ubiquitination and deubiquitination: Implications for the pathogenesis and treatment of osteoarthritis

Ubiquitination and deubiquitination: Implications for the pathogenesis and treatment of osteoarthritis

Osteoarthritis (OA) is a degenerative disease that affects multiple cells and associated extracellular matrix (ECM). Chondrocytes and chondroextracellular matrix together constitute articular cartilage tissue. Any factors that affect the activity of chondrocytes and destroy the metabolic balance of...

Full description

Saved in:

Bibliographic Details
Main Authors:	Shibo Su, Ruijiao Tian, Yang Jiao, Shudan Zheng, Siqiang Liang, Tianyi Liu, Ziheng Tian, Xiuhong Cao, Yanlong Xing, Chuqing Ma, Panli Ni, Fabiao Yu, Tongmeng Jiang, Juan Wang
Format:	Article
Language:	English
Published:	Elsevier 2024-11-01
Series:	Journal of Orthopaedic Translation
Subjects:	Chondrocyte Fibroblast-like synoviocyte (FLS) Macrophage Osteoarthritis Osteoblast Ubiquitination
Online Access:	http://www.sciencedirect.com/science/article/pii/S2214031X2400127X
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The role of ubiquitination and deubiquitination in cancer lipid metabolism
by: Yongkang Xu, et al.
Published: (2025-01-01)

TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study
by: Bo Peng, et al.
Published: (2024-11-01)

Qufeng epimedium decoction alleviates rheumatoid arthritis through CYLD-antagonized NF-kB activation by deubiquitinating Sirt1
by: Zhiming Wu, et al.
Published: (2025-03-01)

Emodin promotes the recovery of rheumatoid arthritis by regulating the crosstalk between macrophage subsets and synovial fibroblast subsets
by: Lianying Cheng, et al.
Published: (2025-01-01)

Development and characterization of an in vitro fluorescently tagged 3D bone-cartilage interface model
by: Mary Adams, et al.
Published: (2024-11-01)

Pathological roles of ubiquitination and deubiquitination systems in sepsis-induced myocardial dysfunction
by: Zhiping Wang, et al.
Published: (2025-01-01)

Enhancing the effectiveness of immunotherapy in rheumatoid arthritis by delaying immunosenescence triggered by fibroblast-like synoviocytes
by: Li Zhang, et al.
Published: (2025-01-01)

Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression
by: Yulan Huang, et al.
Published: (2025-03-01)

Single-cell profiling uncovers synovial fibroblast subpopulations associated with chondrocyte injury in osteoarthritis
by: Zezhong Liu, et al.
Published: (2024-12-01)

Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis
by: Hongyan Qian, et al.
Published: (2024-05-01)

Treatment of rheumatoid arthritis using dual-targeted and dual-response intelligent micelles: a “three birds with one stone” strategy
by: Rui-Bo Guo, et al.
Published: (2025-02-01)

Apurinic/apyrimidinic endonuclease 1 alleviates inflammation in fibroblast-like synoviocytes from patients with rheumatoid arthritis
by: Ha-Reum Lee, et al.
Published: (2024-08-01)

Immunohistochemical investigation of the role of ubiquitin and 8-hydroxyguanosine in pathogenesis of cattle leptospirosis
by: Musa Karaman, et al.

Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway
by: Huan Liu, et al.
Published: (2025-01-01)

Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis
by: Changyuan Huang, et al.
Published: (2025-03-01)

Le jumelage interculturel : une pratique originale pour la formation en FLS au niveau universitaire
by: Myra Deraîche, et al.
Published: (2015-06-01)

Investigation of GPM6B as a novel therapeutic target in Osteoarthritis
by: Chongyang Feng, et al.
Published: (2024-11-01)

The Challenges of Local Intra-Articular Therapy
by: Gailute Kirdaite, et al.
Published: (2024-11-01)

CUL4-Based Ubiquitin Ligases in Chromatin Regulation: An Evolutionary Perspective
by: Makiko Nakagawa, et al.
Published: (2025-01-01)

Unraveling the Role of Ubiquitin-Conjugating Enzyme UBE2T in Tumorigenesis: A Comprehensive Review
by: Chang Gao, et al.
Published: (2024-12-01)

Dysregulation of ubiquitination modification in renal cell carcinoma
by: Hongjie You, et al.
Published: (2024-12-01)

Exploring perinatal mesenchymal stromal cells as a potential therapeutic strategy for rheumatoid arthritis
by: Stefano Alivernini, et al.
Published: (2025-01-01)

Zinc finger protein A20-targeting siRNA promotes pyroptosis of human rheumatoid arthritis fibroblast-like synoviocytes
Published: (2024-10-01)

Down-regulation of FGFR3 expression aggravates the damage of articular chondrocyte superficial zone cells in mice
by: GUAN Yunbo, LI Chao, XU Cheng, SUN Xiaofei, BAI Xuedong, HE Qing, WANG Zuqiang
Published: (2024-11-01)

The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming
by: Bharathi Suresh, et al.
Published: (2016-01-01)

Deubiquitination and stabilization of programmed cell death ligand 1 by ubiquitin‐specific peptidase 9, X‐linked in oral squamous cell carcinoma
by: Wu Jingjing, et al.
Published: (2018-08-01)

Elucidation of Ubiquitin-Related Functions via an Ubiquitin Overexpression Approach
by: Ryo Masuda, et al.
Published: (2024-12-01)

Biocompatibility Analysis of the Silver-Coated Microporous Titanium Implants Manufactured with 3D-Printing Technology
by: Maxim Shevtsov, et al.
Published: (2024-11-01)

Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats
by: Junping Zhu, et al.
Published: (2024-11-01)

LncRNA NONHSAT042241 inhibits rheumatoid synovial proliferation, inflammation and aggression via inactivating WNT/β-catenin signaling pathway
by: Yehua Jin, et al.
Published: (2024-12-01)

Texte littéraire dans l’enseignement du FLS dans le secondaire : quels enjeux ?
by: PREVOST Julie

Structural Optimization of Vertical Axis Wind Turbine (VAWT): A Multi-Variable Study for Enhanced Deflection and Fatigue Performance
by: Sajid Ali, et al.
Published: (2024-12-01)

GGNBP2 regulates histone ubiquitination and methylation in spermatogenesis
by: Kaimin Guo, et al.
Published: (2024-12-01)

A novel ubiquitination-related gene signature for overall survival prediction in patients with liver hepatocellular carcinoma
by: Xiuyun Chen, et al.
Published: (2025-01-01)

Mitochondrial‐Derived Peptide MOTS‐c Suppresses Ovarian Cancer Progression by Attenuating USP7‐Mediated LARS1 Deubiquitination
by: Yadong Yin, et al.
Published: (2024-11-01)

Forward genetic approach identifies a phylogenetically conserved serine residue critical for the catalytic activity of UBIQUITIN-SPECIFIC PROTEASE 12 in Arabidopsis
by: Anita Hajdu, et al.
Published: (2024-10-01)

Research progress on the antiviral immune regulation of ubiquitin ligase F-box family
by: MENG Xiangbo, LI Tianqi, ZHANG Tong
Published: (2025-01-01)

Exploring the role of ubiquitination modifications in migraine headaches
by: Qian Zhu, et al.
Published: (2025-01-01)

Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control
by: Christina Schmidt, et al.
Published: (2025-01-01)

Progranulin deficiency associates with postmenopausal osteoporosis via increasing ubiquitination of estrogen receptor α
by: Guangfei Li, et al.
Published: (2025-01-01)