A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import

Abstract HIV-1 capsids cross nuclear pore complexes (NPCs) by engaging with the nuclear import machinery. To identify compounds that inhibit HIV-1 nuclear import, we screened drugs in silico on a three-dimensional model of a CA hexamer bound by Transportin-1 (TRN-1). Among hits, compound H27 inhibit...

Full description

Saved in:

Bibliographic Details
Main Authors:	Aude Boulay, Emmanuel Quevarec, Isabelle Malet, Giuseppe Nicastro, Célia Chamontin, Suzon Perrin, Corinne Henriquet, Martine Pugnière, Valérie Courgnaud, Mickaël Blaise, Anne-Geneviève Marcelin, Ian A Taylor, Laurent Chaloin, Nathalie J Arhel
Format:	Article
Language:	English
Published:	Springer Nature 2024-10-01
Series:	EMBO Molecular Medicine
Subjects:	HIV-1 Capsid Nuclear Import Drug Discovery Antiretroviral Therapy
Online Access:	https://doi.org/10.1038/s44321-024-00143-w
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!

A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import

Similar Items