Interventions to facilitate return to work in adults with chronic non-malignant pain: a protocol for a systematic review and network meta-analysis
Introduction Work absenteeism due to chronic non-malignant pain (CNMP) is a major societal and individual cause of concern that requires effective treatments.Objective We present a protocol for a systematic review and network meta-analysis (NMA) aiming to compare available interventions for return t...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/11/e040962.full |
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| author | Anna Chaimani Marco Solmi Trevor Thompson Mathilda Björk Björn Gerdle Gunilla Liedberg Frida Svanholm Elena Dragioti |
| author_facet | Anna Chaimani Marco Solmi Trevor Thompson Mathilda Björk Björn Gerdle Gunilla Liedberg Frida Svanholm Elena Dragioti |
| author_sort | Anna Chaimani |
| collection | DOAJ |
| description | Introduction Work absenteeism due to chronic non-malignant pain (CNMP) is a major societal and individual cause of concern that requires effective treatments.Objective We present a protocol for a systematic review and network meta-analysis (NMA) aiming to compare available interventions for return to work (RTW) in adults with CNMP.Methods and analysis PubMed, Embase, PsycINFO, Web of Knowledge and Cochrane Central Register of Controlled Trials databases will be searched till 31 August 2020 for randomised controlled trials (RCTs) examining interventions for RTW outcomes among patients with CNMP. Two independent investigators will search the databases, perform data extraction and assess the methodological quality of the selected RCTs. The primary outcome will be RTW, if possible, full-time or part-time after work absence due to chronic pain from baseline to the last available follow-up. Secondary outcomes will include self-reported workability or work capacity, or self-reported physical functioning and quality of life as measured by any validated scale. Pairwise meta-analysis and NMA will be conducted for each outcome using a random-effects model. For the primary outcomes, we will also obtain the ranking of all competing interventions within each NMA using surface under the cumulative ranking curve. The assumption of coherence (ie, that direct and indirect evidence are in statistical agreement) will be examined using both a local and a global approach. We will also conduct subgroup and meta-regression analyses, whenever feasible, to investigate the unexplained variation in effect size. The comparison-adjusted funnel plot will be used to evaluate small-study effects. The overall quality of evidence will be rated with the Confidence in Network Meta-Analysis tool. Data analysis will be conducted using Stata V.16.0.Ethics and dissemination This systematic review does not require ethical approval since it will not disseminate any private patient data. The results of this study will be disseminated through peer-reviewed publication.PROSPERO registration number CRD42020171429. |
| format | Article |
| id | doaj-art-7cb91d0759ac46318f46b39e9b7ae60d |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-7cb91d0759ac46318f46b39e9b7ae60d2024-11-27T19:10:09ZengBMJ Publishing GroupBMJ Open2044-60552020-11-01101110.1136/bmjopen-2020-040962Interventions to facilitate return to work in adults with chronic non-malignant pain: a protocol for a systematic review and network meta-analysisAnna Chaimani0Marco Solmi1Trevor Thompson2Mathilda Björk3Björn Gerdle4Gunilla Liedberg5Frida Svanholm6Elena Dragioti7Research Center of Epidemiology and Statistics Sorbonne Paris Cité (CRESS UMR1153), INSERM, INRA, Université de Paris, Paris, FranceDepartment of Psychiatry, University of Ottawa, Ottawa, Ontario, Canadaassociate professor of clinical research4Region stergtland, Department of rheumatology, Heart and medicine center, Linkping, SwedenPain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linkopings Universitet, Linkoping, SwedenDepartment of Health Medicine and Caring Sciences, Linkoping University, Linkoping, SwedenPain and Rehabilitation Centre, and Department of Health, Medicine and Caring Sciences, Linköping University, Linkoping, SwedenPain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linkopings universitet, Linkoping, SwedenIntroduction Work absenteeism due to chronic non-malignant pain (CNMP) is a major societal and individual cause of concern that requires effective treatments.Objective We present a protocol for a systematic review and network meta-analysis (NMA) aiming to compare available interventions for return to work (RTW) in adults with CNMP.Methods and analysis PubMed, Embase, PsycINFO, Web of Knowledge and Cochrane Central Register of Controlled Trials databases will be searched till 31 August 2020 for randomised controlled trials (RCTs) examining interventions for RTW outcomes among patients with CNMP. Two independent investigators will search the databases, perform data extraction and assess the methodological quality of the selected RCTs. The primary outcome will be RTW, if possible, full-time or part-time after work absence due to chronic pain from baseline to the last available follow-up. Secondary outcomes will include self-reported workability or work capacity, or self-reported physical functioning and quality of life as measured by any validated scale. Pairwise meta-analysis and NMA will be conducted for each outcome using a random-effects model. For the primary outcomes, we will also obtain the ranking of all competing interventions within each NMA using surface under the cumulative ranking curve. The assumption of coherence (ie, that direct and indirect evidence are in statistical agreement) will be examined using both a local and a global approach. We will also conduct subgroup and meta-regression analyses, whenever feasible, to investigate the unexplained variation in effect size. The comparison-adjusted funnel plot will be used to evaluate small-study effects. The overall quality of evidence will be rated with the Confidence in Network Meta-Analysis tool. Data analysis will be conducted using Stata V.16.0.Ethics and dissemination This systematic review does not require ethical approval since it will not disseminate any private patient data. The results of this study will be disseminated through peer-reviewed publication.PROSPERO registration number CRD42020171429.https://bmjopen.bmj.com/content/10/11/e040962.full |
| spellingShingle | Anna Chaimani Marco Solmi Trevor Thompson Mathilda Björk Björn Gerdle Gunilla Liedberg Frida Svanholm Elena Dragioti Interventions to facilitate return to work in adults with chronic non-malignant pain: a protocol for a systematic review and network meta-analysis BMJ Open |
| title | Interventions to facilitate return to work in adults with chronic non-malignant pain: a protocol for a systematic review and network meta-analysis |
| title_full | Interventions to facilitate return to work in adults with chronic non-malignant pain: a protocol for a systematic review and network meta-analysis |
| title_fullStr | Interventions to facilitate return to work in adults with chronic non-malignant pain: a protocol for a systematic review and network meta-analysis |
| title_full_unstemmed | Interventions to facilitate return to work in adults with chronic non-malignant pain: a protocol for a systematic review and network meta-analysis |
| title_short | Interventions to facilitate return to work in adults with chronic non-malignant pain: a protocol for a systematic review and network meta-analysis |
| title_sort | interventions to facilitate return to work in adults with chronic non malignant pain a protocol for a systematic review and network meta analysis |
| url | https://bmjopen.bmj.com/content/10/11/e040962.full |
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