Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins

Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins

Abstract Background Cancer creates an immunosuppressive environment that hampers immune responses, allowing tumors to grow and resist therapy. One way the immune system fights back is by inducing ferroptosis, a type of cell death, in tumor cells through CD8 + T cells. This involves lipid peroxidatio...

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Main Authors: Maria Angelica Freitas-Cortez, Fatemeh Masrorpour, Hong Jiang, Iqbal Mahmud, Yue Lu, Ailing Huang, Lisa K. Duong, Qi Wang, Tiffany A. Voss, Claudia S. Kettlun Leyton, Bo Wei, Wai-Kin Chan, Kevin Lin, Jie Zhang, Efrosini Tsouko, Shonik Ganjoo, Hampartsoum B. Barsoumian, Thomas S. Riad, Yun Hu, Carola Leuschner, Nahum Puebla-Osorio, Jing Wang, Jian Hu, Michael A. Davies, Vinay K. Puduvalli, Cyrielle Billon, Thomas P. Burris, Philip L. Lorenzi, Boyi Gan, James W. Welsh
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Molecular Cancer
Subjects:
FABP7
Ferroptosis
Lpcat3
Bmal1
Circadian clock
Immunotherapy
Online Access:https://doi.org/10.1186/s12943-024-02198-2
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