Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin
Glycidol is a common lipid-derived foodborne toxicant mainly presents in refined oils and related foodstuffs. Vascular endothelial cells may be potential targets of the deleterious effects associated with glycidol exposure. In human umbilical vein endothelial cells (HUVECs), we found that glycidol t...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250207 |
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| author | Yue Zhou Hui Xu Ka-Wing Cheng Feng Chen Qian Zhou Mingfu Wang |
| author_facet | Yue Zhou Hui Xu Ka-Wing Cheng Feng Chen Qian Zhou Mingfu Wang |
| author_sort | Yue Zhou |
| collection | DOAJ |
| description | Glycidol is a common lipid-derived foodborne toxicant mainly presents in refined oils and related foodstuffs. Vascular endothelial cells may be potential targets of the deleterious effects associated with glycidol exposure. In human umbilical vein endothelial cells (HUVECs), we found that glycidol treatment promoted endothelialto-mesenchymal transition (EndMT) at a lower concentration (0.5 mmol/L), while induced apoptosis and inflammation at a higher concentration (1 mmol/L). These harmful effects were achieved by the activation of NF-κB/MAPK signaling pathway and were mediated by reactive oxygen species (ROS). In addition, the protective potential of 6-C-(E-2-fluorostyryl)naringenin (6-CEFN) against glycidol was evaluated and compared with naringenin. HUVECs pre-treated with 6-CEFN, but not naringenin, displayed resistance to endothelial dysfunction caused by glycidol. |
| format | Article |
| id | doaj-art-7ca0c2c412f3479eb3a6084aeb557eaa |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-7ca0c2c412f3479eb3a6084aeb557eaa2025-01-10T06:56:56ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-09-011352584259410.26599/FSHW.2022.9250207Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringeninYue Zhou0Hui Xu1Ka-Wing Cheng2Feng Chen3Qian Zhou4Mingfu Wang5College of Civil and Transportation Engineering/College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, ChinaCollege of Civil and Transportation Engineering/College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, ChinaCollege of Civil and Transportation Engineering/College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, ChinaCollege of Civil and Transportation Engineering/College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, ChinaCollege of Civil and Transportation Engineering/College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, ChinaCollege of Civil and Transportation Engineering/College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, ChinaGlycidol is a common lipid-derived foodborne toxicant mainly presents in refined oils and related foodstuffs. Vascular endothelial cells may be potential targets of the deleterious effects associated with glycidol exposure. In human umbilical vein endothelial cells (HUVECs), we found that glycidol treatment promoted endothelialto-mesenchymal transition (EndMT) at a lower concentration (0.5 mmol/L), while induced apoptosis and inflammation at a higher concentration (1 mmol/L). These harmful effects were achieved by the activation of NF-κB/MAPK signaling pathway and were mediated by reactive oxygen species (ROS). In addition, the protective potential of 6-C-(E-2-fluorostyryl)naringenin (6-CEFN) against glycidol was evaluated and compared with naringenin. HUVECs pre-treated with 6-CEFN, but not naringenin, displayed resistance to endothelial dysfunction caused by glycidol.https://www.sciopen.com/article/10.26599/FSHW.2022.9250207glycidolendothelial cells6-c-(e-2-fluorostyryl)naringeninoxidative stressendothelial-to-mesenchymal transition |
| spellingShingle | Yue Zhou Hui Xu Ka-Wing Cheng Feng Chen Qian Zhou Mingfu Wang Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin Food Science and Human Wellness glycidol endothelial cells 6-c-(e-2-fluorostyryl)naringenin oxidative stress endothelial-to-mesenchymal transition |
| title | Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin |
| title_full | Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin |
| title_fullStr | Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin |
| title_full_unstemmed | Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin |
| title_short | Oxidative stress mediates glycidol-induced endothelial injury and its protection by 6-C-(E-2-fluorostyryl)naringenin |
| title_sort | oxidative stress mediates glycidol induced endothelial injury and its protection by 6 c e 2 fluorostyryl naringenin |
| topic | glycidol endothelial cells 6-c-(e-2-fluorostyryl)naringenin oxidative stress endothelial-to-mesenchymal transition |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250207 |
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