Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex

Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex

Summary: Chromatin regulatory proteins are expressed broadly and assumed to exert the same intrinsic function across cell types. Here, we report that 14 chromatin regulators undergo evolutionary-conserved neuron-specific splicing events involving microexons. Among them are two components of a histon...

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Bibliographic Details
Main Authors: Robert S. Porter, Sojin An, Maria C. Gavilan, Masayoshi Nagai, Yumie Murata-Nakamura, Bo Zhou, Katherine M. Bonefas, Olivier Dionne, Jeru Manoj Manuel, Joannie St-Germain, Suzanne Gascon, Jacqueline Kim, Liam Browning, Benoit Laurent, Uhn-Soo Cho, Shigeki Iwase
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472401564X
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