Immune regulatory adjuvant approach to mitigate subcutaneous immunogenicity of monoclonal antibodies

Immune regulatory adjuvant approach to mitigate subcutaneous immunogenicity of monoclonal antibodies

IntroductionImmunogenicity continues to be a challenge for development and clinical utility of monoclonal antibodies, and there are gaps in our current ability to prevent anti-drug antibody development in a safe and antigen-specific manner.MethodsTo mitigate immunogenicity of monoclonal antibodies a...

Full description

Saved in:

Bibliographic Details
Main Authors:	Nicole L. Jarvi, Manali Patel, Krithika A. Shetty, Nhan H. Nguyen, Brooke F. Grasperge, Donald E. Mager, Robert M. Straubinger, Sathy V. Balu-Iyer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Series:	Frontiers in Immunology
Subjects:	protein therapeutics immunogenicity immune tolerance anti-drug antibodies subcutaneous administration formulation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1496169/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Scapular swelling: “subcutaneous cysticercosis unveiled”—a case report
by: Barundeep Singh, et al.
Published: (2024-12-01)

Subcutaneous drug administration in palliative care
by: Carmen Matoses Chirivella, et al.
Published: (2015-01-01)

Reactogenicity and Immunogenicity Against MPXV of the Intradermal Administration of Modified Vaccinia Ankara Compared to the Standard Subcutaneous Route
by: Valentina Mazzotta, et al.
Published: (2024-12-01)

Generalized subcutaneous emphysema (pnenmoderma) in a dog
by: İlker Çamkerten, et al.

Predicting the clinical subcutaneous absorption rate constant of monoclonal antibodies using only the primary sequence: a machine learning approach
by: Ronghua Bei, et al.
Published: (2024-12-01)

Subcutaneous calcinosis as a harbinger of infection in a patient with relapsing dermatomyositis
by: Ansh Bhatia, et al.
Published: (2022-01-01)

Traumatic Tension Pneumothorax with Extensive Subcutaneous Emphysema
by: Hojat Rastegari, et al.
Published: (2024-05-01)

Effect of primary closure of subcutaneous cellular tissue on the incidence of seromas in laparotomy wounds
by: Luis R. Gómez-Álvarez, et al.
Published: (2024-10-01)

Investigation of pharmacokinetics and immunogenicity of magnetosomes
by: M. Haripriyaa, et al.
Published: (2024-12-01)

Subcutaneous immunoglobulin-induced eczematous dermatitis
by: Rachel Breidbart, BS, et al.
Published: (2025-02-01)

Human dirofilariasis – Unforeseen lesion in subcutaneous nodules: Case series from a tertiary care hospital, Wayanad
by: M M Gitanjali, et al.
Published: (2023-02-01)

Relevance of Lumbar Subcutaneous Edema and Local Lordosis
by: Kazuma DOI, et al.
Published: (2024-12-01)

Hematological and biochemical effect of subcutaneous administration of robenacoxib in different goat breeds
by: Zeynep Ozdemir Kutahya, et al.
Published: (2023-12-01)

Development and validation of a prognostic nomogram model in primary cutaneous and subcutaneous soft tissue angiosarcoma
by: Jinqian Mao, et al.
Published: (2022-07-01)

Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals
by: Sophie Tourdot, et al.
Published: (2024-12-01)

Preliminary results on novel adjuvant combinations suggest enhanced immunogenicity of whole inactivated pandemic influenza vaccines
by: Allegra Peletta, et al.
Published: (2024-07-01)

Neuron-derived neurotrophic factor promotes the differentiation of intramuscular and subcutaneous adipocytes in goat
by: An Li, et al.
Published: (2024-12-01)

Incidence and Extent of Bruising After Subcutaneous Injection of Enoxaparin Sodium in Patients Hospitalized at Coronary Care Units
by: Zeynab Poursafar, et al.
Published: (2019-04-01)

Corrigendum: Preliminary results on novel adjuvant combinations suggest enhancement immunogenicity of whole inactivated pandemic influenza vaccines
by: Allegra Peletta, et al.
Published: (2024-12-01)

Subcutaneous Pectoral Edema After Arthroscopic Labral Repair Despite Normal Irrigation Fluid Usage and Surgery Duration
by: İnci Hazal Ayas, et al.
Published: (2025-02-01)

A rare case of pneumomediastinum, pneumoretroperitoneum and subcutaneous emphysema due to crystal methamphetamine abuse
by: Abdulmajeed K. Abdulmajeed, et al.
Published: (2024-12-01)

A study on subcutaneous infection model of colibacillosis in broilers: Selected immunological and hematological aspects
by: Z. Ghahramani, et al.
Published: (2024-12-01)

Immunogenic chemotherapy sensitizes RAS-mutated colorectal cancers to immune checkpoint inhibitors
by: Lucillia Bezu, et al.
Published: (2023-12-01)

Assessment of Microcirculatory Dysfunction by Measuring Subcutaneous Tissue Oxygen Saturation Using Near-Infrared Spectroscopy in Patients with Circulatory Failure
by: Jun Sato, et al.
Published: (2024-10-01)

Multiloculated pyopneumothorax with subcutaneous emphysema and pneumomediastinum in a tuberculosis patient
by: Qura Tul Ain, et al.
Published: (2024-12-01)

Immunogenicity and Safety of the Recombinant Adjuvanted Herpes Zoster Vaccine in Patients with Chronic Lymphocytic Leukemia and Multiple Myeloma
by: Panagiotis T. Diamantopoulos, et al.
Published: (2024-10-01)

Immunogenicity of red blood cell blood group antigens in the population of Xi'an
by: ZHANG Liangzi, et al.
Published: (2024-12-01)

Case Report: An exceptional localisation in the thigh of a giant primary subcutaneous hydatid cyst. [version 1; peer review: 2 approved]
by: Ikram Haddada, et al.
Published: (2024-10-01)

Treatment of Severe Hyperglycemia in Extremely Preterm Infants Using Continuous Subcutaneous Insulin Therapy
by: Merle Böettger, et al.
Published: (2024-12-01)

Nicolau syndrome: A case of ischemic necrosis after subcutaneous immunotherapy
by: Joyce Kim, MD, et al.
Published: (2025-02-01)

Research progress on subcutaneous specific immunotherapy of dust mite allergens in children
by: LIU Xiao, LI Jiayu, CHEN Zhuanggui, ZHANG Pingping
Published: (2024-11-01)

Comparison of continuous subcutaneous hydromorphone hydrochloride and morphine hydrochloride injection on skin disorders incidence: a retrospective study
by: Rei Tanaka, et al.
Published: (2024-12-01)

Ultrasound Examination of Skin, Fasciae and Subcutaneous Tissue: Optimizing Rehabilitation for Secondary Upper Limb Lymphedema
by: Carmelo Pirri, et al.
Published: (2024-12-01)

Zoonotic Dirofilaria sp. “hongkongensis” in subcutaneous nodules from dogs and cats, Hong Kong SAR
by: Thamali Manathunga, et al.
Published: (2024-11-01)

Immunogenic oncolysis by tigilanol tiglate
by: Jonathan G. Pol, et al.
Published: (2024-12-01)

Mutations in the <i>A34R</i> gene increase the immunogenicity of vaccinia virus
by: S. N. Shchelkunov, et al.
Published: (2021-04-01)

Immunogenicity of Local and Massachusetts Strains Infectious Bronchitis Virus
by: Jola Rahmahani, et al.
Published: (2022-04-01)

Influvac Tetra: clinical experience on safety, efficacy, and immunogenicity
by: Laura Colombo, et al.
Published: (2024-12-01)

A unique presentation of subcutaneous Cutaneotrichosporon debeurmannianum infection: A case report of a diagnostic challenge
by: Agustin N. Posso, et al.
Published: (2024-12-01)

Triple-negative breast cancer patients treated with subcutaneous mastectomy with immediate reconstruction: single institution experience
by: Artur Bocian, et al.
Published: (2024-12-01)