A validated high-performance liquid chromatography-ultraviolet method for the determination of valproic acid derivatives in pharmaceutical formulations with a microbiological suitability evaluation

A validated high-performance liquid chromatography-ultraviolet method for the determination of valproic acid derivatives in pharmaceutical formulations with a microbiological suitability evaluation

Valproic acid and its derivatives are common drugs used in the treatment of epilepsy, a result of CNS disorders. Because the molecular structure of valproic acid, as a fatty acid, does not contain any chromophore groups, its peak response demanded special conditions to be detected in HPLC, ensuring...

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Bibliographic Details
Main Authors: Abdullah H. Alluhayb, Mostafa F. Al-Hakkani, Mahmoud Abdulnasser, Bandar R. Alsehli, Mohammed S. Saddik, Mohammad H.A. Hassan, Sayed M Saleh
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Talanta Open
Subjects:
HPLC
Validation
Valproic acid
Sodium divalproex
Microbiological suitability
Limit of detection, LOQ
Online Access:http://www.sciencedirect.com/science/article/pii/S2666831924000791
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