Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine
CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated proteins) has undergone marked advancements since its discovery as an adaptive immune system in bacteria and archaea, emerged as a potent gene-editing tool after the successful engineering of its synthetic guide...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Genome Editing |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgeed.2024.1509924/full |
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| author | Sarkar Sardar Azeez Rahin Shareef Hamad Bahra Kakamin Hamad Mudhir Sabir Shekha Mudhir Sabir Shekha Peter Bergsten |
| author_facet | Sarkar Sardar Azeez Rahin Shareef Hamad Bahra Kakamin Hamad Mudhir Sabir Shekha Mudhir Sabir Shekha Peter Bergsten |
| author_sort | Sarkar Sardar Azeez |
| collection | DOAJ |
| description | CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated proteins) has undergone marked advancements since its discovery as an adaptive immune system in bacteria and archaea, emerged as a potent gene-editing tool after the successful engineering of its synthetic guide RNA (sgRNA) toward the targeting of specific DNA sequences with high accuracy. Besides its DNA editing ability, further-developed Cas variants can also edit the epigenome, rendering the CRISPR-Cas system a versatile tool for genome and epigenome manipulation and a pioneering force in precision medicine. This review explores the latest advancements in CRISPR-Cas technology and its therapeutic and biomedical applications, highlighting its transformative impact on precision medicine. Moreover, the current status of CRISPR therapeutics in clinical trials is discussed. Finally, we address the persisting challenges and prospects of CRISPR-Cas technology. |
| format | Article |
| id | doaj-art-7c53ab95d57b4559b59b520534ac9fcd |
| institution | Kabale University |
| issn | 2673-3439 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genome Editing |
| spelling | doaj-art-7c53ab95d57b4559b59b520534ac9fcd2024-12-12T06:18:38ZengFrontiers Media S.A.Frontiers in Genome Editing2673-34392024-12-01610.3389/fgeed.2024.15099241509924Advances in CRISPR-Cas technology and its applications: revolutionising precision medicineSarkar Sardar Azeez0Rahin Shareef Hamad1Bahra Kakamin Hamad2Mudhir Sabir Shekha3Mudhir Sabir Shekha4Peter Bergsten5Department of Medical Laboratory Technology, Soran Technical College, Erbil Polytechnic University, Erbil, Kurdistan Region, IraqNursing Department, Soran Technical College, Erbil Polytechnic University, Erbil, Kurdistan Region, IraqDepartment of Medical Laboratory Technology, Erbil Health and Medical Technical College, Erbil Polytechnic University, Erbil, Kurdistan Region, IraqDepartment of Biology, College of Science, Salahaddin University, Erbil, Kurdistan Region, IraqDepartment of Medical Cell Biology, Uppsala University, Uppsala, SwedenDepartment of Medical Cell Biology, Uppsala University, Uppsala, SwedenCRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated proteins) has undergone marked advancements since its discovery as an adaptive immune system in bacteria and archaea, emerged as a potent gene-editing tool after the successful engineering of its synthetic guide RNA (sgRNA) toward the targeting of specific DNA sequences with high accuracy. Besides its DNA editing ability, further-developed Cas variants can also edit the epigenome, rendering the CRISPR-Cas system a versatile tool for genome and epigenome manipulation and a pioneering force in precision medicine. This review explores the latest advancements in CRISPR-Cas technology and its therapeutic and biomedical applications, highlighting its transformative impact on precision medicine. Moreover, the current status of CRISPR therapeutics in clinical trials is discussed. Finally, we address the persisting challenges and prospects of CRISPR-Cas technology.https://www.frontiersin.org/articles/10.3389/fgeed.2024.1509924/fullCRISPR-Cas9genome editingepigenome modulationcancer immunotherapyand CRISPR in clinical trials |
| spellingShingle | Sarkar Sardar Azeez Rahin Shareef Hamad Bahra Kakamin Hamad Mudhir Sabir Shekha Mudhir Sabir Shekha Peter Bergsten Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine Frontiers in Genome Editing CRISPR-Cas9 genome editing epigenome modulation cancer immunotherapy and CRISPR in clinical trials |
| title | Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine |
| title_full | Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine |
| title_fullStr | Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine |
| title_full_unstemmed | Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine |
| title_short | Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine |
| title_sort | advances in crispr cas technology and its applications revolutionising precision medicine |
| topic | CRISPR-Cas9 genome editing epigenome modulation cancer immunotherapy and CRISPR in clinical trials |
| url | https://www.frontiersin.org/articles/10.3389/fgeed.2024.1509924/full |
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