The effects of acute exercise on emotional pattern separation in adolescents and young adults
Acute exercise has been associated with cognitive improvements, particularly in memory processes linked to the hippocampus, such as the ability to discriminate between similar stimuli, called hippocampal pattern separation. This can be assessed behaviorally with a mnemonic discrimination task and ne...
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Elsevier
2025-01-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811924004567 |
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| author | Lise Jennen Victor Mazereel Davy Vancampfort Zhiling Qiao Kristof Vansteelandt Patrick Dupont Aleksandra Lecei Ruud van Winkel |
| author_facet | Lise Jennen Victor Mazereel Davy Vancampfort Zhiling Qiao Kristof Vansteelandt Patrick Dupont Aleksandra Lecei Ruud van Winkel |
| author_sort | Lise Jennen |
| collection | DOAJ |
| description | Acute exercise has been associated with cognitive improvements, particularly in memory processes linked to the hippocampus, such as the ability to discriminate between similar stimuli, called hippocampal pattern separation. This can be assessed behaviorally with a mnemonic discrimination task and neurally with functional magnetic resonance imaging (fMRI). Additionally, previous research has shown an emotional modulatory effect on pattern separation, involving the amygdala. In this randomized between-subject study, we investigated whether a 10-minute bout of moderate-intensity exercise, compared to rest, could enhance pattern separation of neutral and emotional images in a group of healthy adolescents and young adults (n=53). Our results showed no significant effects of exercise on either mnemonic discrimination performance or neural activity in the hippocampus and amygdala. Additionally, arterial spin labeling (ASL) confirmed that there were no significant differences in cerebral blood flow between exercise and rest. We did observe worse discrimination for images with a higher similarity level and worse discrimination for highly similar positive images compared to negative and neutral images. However, there were no significant correlations between behavioral outcomes and neural activity. Exploratory analysis revealed a neural signal consistent with pattern completion in the bilateral CA1 and left CA3, but no evidence of pattern separation. Future studies should optimize the exercise characteristics necessary to robustly enhance pattern separation. |
| format | Article |
| id | doaj-art-7c4d673401a64c67bcf66e5d94b6952c |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-7c4d673401a64c67bcf66e5d94b6952c2025-01-11T06:38:30ZengElsevierNeuroImage1095-95722025-01-01305120959The effects of acute exercise on emotional pattern separation in adolescents and young adultsLise Jennen0Victor Mazereel1Davy Vancampfort2Zhiling Qiao3Kristof Vansteelandt4Patrick Dupont5Aleksandra Lecei6Ruud van Winkel7KU Leuven, Department of Neurosciences, Center for Clinical Psychiatry, ON5b Herestraat 49, bus 1029, 3000, Leuven, Belgium; Corresponding author at: ON5b Herestraat 49, bus 1029, 3000, Leuven, Belgium.KU Leuven, Department of Neurosciences, Center for Clinical Psychiatry, ON5b Herestraat 49, bus 1029, 3000, Leuven, Belgium; University Psychiatric Center KU Leuven, Leuvensesteenweg 517, 3070, Leuven-Kortenberg, BelgiumUniversity Psychiatric Center KU Leuven, Leuvensesteenweg 517, 3070, Leuven-Kortenberg, Belgium; KU Leuven Department of Rehabilitation Sciences, ON4 Herestraat 49, bus 1510, 3000, Leuven, BelgiumKU Leuven, Department of Neurosciences, Center for Clinical Psychiatry, ON5b Herestraat 49, bus 1029, 3000, Leuven, BelgiumUniversity Psychiatric Center KU Leuven, Leuvensesteenweg 517, 3070, Leuven-Kortenberg, BelgiumKU Leuven, Department of Neurosciences, Laboratory for Cognitive Neurology, ON5 Herestraat 49, bus 1020, 3000, Leuven, BelgiumKU Leuven, Department of Neurosciences, Center for Clinical Psychiatry, ON5b Herestraat 49, bus 1029, 3000, Leuven, BelgiumKU Leuven, Department of Neurosciences, Center for Clinical Psychiatry, ON5b Herestraat 49, bus 1029, 3000, Leuven, Belgium; University Psychiatric Center KU Leuven, Leuvensesteenweg 517, 3070, Leuven-Kortenberg, BelgiumAcute exercise has been associated with cognitive improvements, particularly in memory processes linked to the hippocampus, such as the ability to discriminate between similar stimuli, called hippocampal pattern separation. This can be assessed behaviorally with a mnemonic discrimination task and neurally with functional magnetic resonance imaging (fMRI). Additionally, previous research has shown an emotional modulatory effect on pattern separation, involving the amygdala. In this randomized between-subject study, we investigated whether a 10-minute bout of moderate-intensity exercise, compared to rest, could enhance pattern separation of neutral and emotional images in a group of healthy adolescents and young adults (n=53). Our results showed no significant effects of exercise on either mnemonic discrimination performance or neural activity in the hippocampus and amygdala. Additionally, arterial spin labeling (ASL) confirmed that there were no significant differences in cerebral blood flow between exercise and rest. We did observe worse discrimination for images with a higher similarity level and worse discrimination for highly similar positive images compared to negative and neutral images. However, there were no significant correlations between behavioral outcomes and neural activity. Exploratory analysis revealed a neural signal consistent with pattern completion in the bilateral CA1 and left CA3, but no evidence of pattern separation. Future studies should optimize the exercise characteristics necessary to robustly enhance pattern separation.http://www.sciencedirect.com/science/article/pii/S1053811924004567ExercisePattern separationMnemonic discriminationFunctional magnetic resonance imagingArterial spin labelingAdolescence |
| spellingShingle | Lise Jennen Victor Mazereel Davy Vancampfort Zhiling Qiao Kristof Vansteelandt Patrick Dupont Aleksandra Lecei Ruud van Winkel The effects of acute exercise on emotional pattern separation in adolescents and young adults NeuroImage Exercise Pattern separation Mnemonic discrimination Functional magnetic resonance imaging Arterial spin labeling Adolescence |
| title | The effects of acute exercise on emotional pattern separation in adolescents and young adults |
| title_full | The effects of acute exercise on emotional pattern separation in adolescents and young adults |
| title_fullStr | The effects of acute exercise on emotional pattern separation in adolescents and young adults |
| title_full_unstemmed | The effects of acute exercise on emotional pattern separation in adolescents and young adults |
| title_short | The effects of acute exercise on emotional pattern separation in adolescents and young adults |
| title_sort | effects of acute exercise on emotional pattern separation in adolescents and young adults |
| topic | Exercise Pattern separation Mnemonic discrimination Functional magnetic resonance imaging Arterial spin labeling Adolescence |
| url | http://www.sciencedirect.com/science/article/pii/S1053811924004567 |
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