CYP3A4-mediated metabolism of artemisinin to 10β-hydroxyartemisinin with comparable anti-malarial potency

CYP3A4-mediated metabolism of artemisinin to 10β-hydroxyartemisinin with comparable anti-malarial potency

Abstract Background The most widely used anti-malarial drug artemisinin (ART) is metabolized extensively, but the therapeutic capacity of its major metabolite remains unknown. Whether the major metabolite of ART (ART-M) contributes to its antiplasmodial potency was investigated in this study. Method...

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Bibliographic Details
Main Authors: Fanping Zhu, Huixiu Mao, Shanshan Du, Hongchang Zhou, Rui Zhang, Pingli Li, Jie Xing
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Malaria Journal
Subjects:
Artemisinin
Major metabolite
Metabolizing enzyme
Antiplasmodial activity
Pharmacokinetics
Online Access:https://doi.org/10.1186/s12936-024-05163-y
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https://doi.org/10.1186/s12936-024-05163-y

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