Association of triglyceride glucose index combined with obesity indicators with cognitive impairment
Abstract Background The association of a combination of the TyG index and obesity markers, specifically waist circumference (WC), with cognitive function is unknown. This research investigated the relationship between TyG-WC measurements and cognitive impairment in a low-income population in China;...
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| Format: | Article |
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BMC
2024-11-01
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| Series: | Lipids in Health and Disease |
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| Online Access: | https://doi.org/10.1186/s12944-024-02388-3 |
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| author | Juan Hao Yuting Lu Lei Zhang Xiao Li Haotian Wen Xiyu Zhao Lifeng Wang Jun Tu Jinghua Wang Chunsheng Yang Xianjia Ning Yan Li |
| author_facet | Juan Hao Yuting Lu Lei Zhang Xiao Li Haotian Wen Xiyu Zhao Lifeng Wang Jun Tu Jinghua Wang Chunsheng Yang Xianjia Ning Yan Li |
| author_sort | Juan Hao |
| collection | DOAJ |
| description | Abstract Background The association of a combination of the TyG index and obesity markers, specifically waist circumference (WC), with cognitive function is unknown. This research investigated the relationship between TyG-WC measurements and cognitive impairment in a low-income population in China; moreover, this study evaluated the role of diabetes mellitus and body mass index (BMI) in modulating this relationship. Methods 1125 eligible individuals aged ≥ 60 years participated in this study. The TyG index and obesity indicators (BMI, WC, and waist-to-height ratio) were calculated for individual participants and categorized into quartiles. Multivariate logistic regression analysis was used to evaluate the correlation between TyG-WC values and cognitive impairment; the possibility of a nonlinear relationship was explored using constrained cubic spline analysis. The participants were divided into different groups according to their diabetes status and BMI category for subgroup analyses. Linear regression was used to investigate the correlation between TyG-WC values and MMSE scores. Results The prevalence of cognitive impairment in the study participants was 47.3%, with a significant negative association between TyG-WC values and cognitive impairment, (odds ratio [OR] = 0.999; 95% confidence interval [CI], 0.997–1.00, P = 0.009). A U-shaped correlation was observed between the TyG-WC values and cognitive impairment (P = 0.008). Subgroup analyses showed that the inverse association between TyG-WC values and cognitive impairment was stronger in non-diabetic individuals (OR = 0.998; 95% CI, 0.997–0.999; P = 0.002) and in those with a lower BMI (< 24 kg/m2; OR = 0.996; 95% CI, 0.994–0.998; P = 0.001). A positive correlation was found between TyG-WC values and MMSE scores, particularly in men and non-diabetic individuals (β = 0.003; 95% CI, 0.0002–0.005; P = 0.031). Conclusion This study demonstrates a nonlinear U-shaped relationship between TyG-WC values and cognitive function. The stronger inverse association between TyG-WC values and cognitive decline in the non-diabetic and low-BMI subgroups suggests that these populations may benefit the most from targeted interventions. These findings are important for clinical practice and formulating disease-prevention policies, emphasizing the need for metabolic health management to prevent cognitive decline, particularly in low-income populations. |
| format | Article |
| id | doaj-art-7c34c72d39484fe1bcc87cd44ced235c |
| institution | Kabale University |
| issn | 1476-511X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj-art-7c34c72d39484fe1bcc87cd44ced235c2024-12-01T12:42:44ZengBMCLipids in Health and Disease1476-511X2024-11-0123111210.1186/s12944-024-02388-3Association of triglyceride glucose index combined with obesity indicators with cognitive impairmentJuan Hao0Yuting Lu1Lei Zhang2Xiao Li3Haotian Wen4Xiyu Zhao5Lifeng Wang6Jun Tu7Jinghua Wang8Chunsheng Yang9Xianjia Ning10Yan Li11Department of Neurology, Tianjin Medical University General HospitalSchool of Basic Medical Sciences, Tianjin Medical UniversityTianjin Medical University Jizhou Clinical CollegeDepartment of Neurology, Tianjin Medical University General HospitalThe First Clinical School of Southern Medical UniversityDepartment of Critical Care Medicine, Tianjin Jizhou People’s HospitalTianjin Medical University Jizhou Clinical College；Institute of Clinical Epidemiology & Evidence-Based Medicine, Tianjin Jizhou People’s HospitalDepartment of Neurology, Tianjin Medical University General HospitalDepartment of Neurology, Tianjin Medical University General HospitalDepartment of Neurology, Tianjin Medical University General HospitalDepartment of Neurology, Tianjin Medical University General HospitalTianjin Medical University Jizhou Clinical College；Institute of Clinical Epidemiology & Evidence-Based Medicine, Tianjin Jizhou People’s HospitalAbstract Background The association of a combination of the TyG index and obesity markers, specifically waist circumference (WC), with cognitive function is unknown. This research investigated the relationship between TyG-WC measurements and cognitive impairment in a low-income population in China; moreover, this study evaluated the role of diabetes mellitus and body mass index (BMI) in modulating this relationship. Methods 1125 eligible individuals aged ≥ 60 years participated in this study. The TyG index and obesity indicators (BMI, WC, and waist-to-height ratio) were calculated for individual participants and categorized into quartiles. Multivariate logistic regression analysis was used to evaluate the correlation between TyG-WC values and cognitive impairment; the possibility of a nonlinear relationship was explored using constrained cubic spline analysis. The participants were divided into different groups according to their diabetes status and BMI category for subgroup analyses. Linear regression was used to investigate the correlation between TyG-WC values and MMSE scores. Results The prevalence of cognitive impairment in the study participants was 47.3%, with a significant negative association between TyG-WC values and cognitive impairment, (odds ratio [OR] = 0.999; 95% confidence interval [CI], 0.997–1.00, P = 0.009). A U-shaped correlation was observed between the TyG-WC values and cognitive impairment (P = 0.008). Subgroup analyses showed that the inverse association between TyG-WC values and cognitive impairment was stronger in non-diabetic individuals (OR = 0.998; 95% CI, 0.997–0.999; P = 0.002) and in those with a lower BMI (< 24 kg/m2; OR = 0.996; 95% CI, 0.994–0.998; P = 0.001). A positive correlation was found between TyG-WC values and MMSE scores, particularly in men and non-diabetic individuals (β = 0.003; 95% CI, 0.0002–0.005; P = 0.031). Conclusion This study demonstrates a nonlinear U-shaped relationship between TyG-WC values and cognitive function. The stronger inverse association between TyG-WC values and cognitive decline in the non-diabetic and low-BMI subgroups suggests that these populations may benefit the most from targeted interventions. These findings are important for clinical practice and formulating disease-prevention policies, emphasizing the need for metabolic health management to prevent cognitive decline, particularly in low-income populations.https://doi.org/10.1186/s12944-024-02388-3Cognitive impairmentTyG-WCMetabolic healthBMIDiabetes mellitus |
| spellingShingle | Juan Hao Yuting Lu Lei Zhang Xiao Li Haotian Wen Xiyu Zhao Lifeng Wang Jun Tu Jinghua Wang Chunsheng Yang Xianjia Ning Yan Li Association of triglyceride glucose index combined with obesity indicators with cognitive impairment Lipids in Health and Disease Cognitive impairment TyG-WC Metabolic health BMI Diabetes mellitus |
| title | Association of triglyceride glucose index combined with obesity indicators with cognitive impairment |
| title_full | Association of triglyceride glucose index combined with obesity indicators with cognitive impairment |
| title_fullStr | Association of triglyceride glucose index combined with obesity indicators with cognitive impairment |
| title_full_unstemmed | Association of triglyceride glucose index combined with obesity indicators with cognitive impairment |
| title_short | Association of triglyceride glucose index combined with obesity indicators with cognitive impairment |
| title_sort | association of triglyceride glucose index combined with obesity indicators with cognitive impairment |
| topic | Cognitive impairment TyG-WC Metabolic health BMI Diabetes mellitus |
| url | https://doi.org/10.1186/s12944-024-02388-3 |
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