Innovative chitosan/graphene oxide composites: A thermodynamic and calorimetric approach to pharmaceutical waste removal from water
The study explores the adsorption behavior of pharmaceutical molecules, including the antiepileptic drug Levetiracetam (LEV), Ketorolac Tromethamine (KT), and Mefenamic Acid (MA), using bioadsorbents based on chitosan and graphene derivatives. Chitosan, derived from crab shell chitin, was blended wi...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Results in Engineering |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590123024019406 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846100617857073152 |
|---|---|
| author | Liliana Giraldo Carlos A. Guerrero Fajardo Juan Carlos Moreno Piraján |
| author_facet | Liliana Giraldo Carlos A. Guerrero Fajardo Juan Carlos Moreno Piraján |
| author_sort | Liliana Giraldo |
| collection | DOAJ |
| description | The study explores the adsorption behavior of pharmaceutical molecules, including the antiepileptic drug Levetiracetam (LEV), Ketorolac Tromethamine (KT), and Mefenamic Acid (MA), using bioadsorbents based on chitosan and graphene derivatives. Chitosan, derived from crab shell chitin, was blended with graphene oxide (GO) and reduced graphene oxide (rGO) at varying concentrations (0.05 % and 0.5 %) to assess its impact on adsorption performance and material properties. Composites containing 0.5 % GO and rGO demonstrated the highest adsorption capacities, achieving maximum values of 30.85mg/g for KT on rGO and 29.74mg/g on GO. Adsorption equilibrium was rapidly attained, typically within 10 min to a few hours, and the process conformed to a pseudo-second-order kinetic model. Adsorption isotherms were best described by the Sips model, suggesting increased capacity with rising temperature, consistent with results from immersion calorimetry. Optimal adsorption occurred at a pH of 5.5 and a temperature of 60 °C. Comprehensive characterization using N2 and CO2 adsorption isotherms, FTIR, Raman spectroscopy, and pHpzc measurements validated the physical and chemical properties of the adsorbents. Thermodynamic analyses revealed spontaneous and exothermic adsorption interactions, with enthalpy values indicative of physical adsorption mechanisms. These findings underscore the potential of these chitosan-based bioadsorbents for the efficient removal of pharmaceutical molecules, demonstrating their applicability in environmental remediation and water purification technologies. |
| format | Article |
| id | doaj-art-7c34bfa5fe4049c584002a576a565ef3 |
| institution | Kabale University |
| issn | 2590-1230 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Engineering |
| spelling | doaj-art-7c34bfa5fe4049c584002a576a565ef32024-12-30T04:15:55ZengElsevierResults in Engineering2590-12302025-03-0125103697Innovative chitosan/graphene oxide composites: A thermodynamic and calorimetric approach to pharmaceutical waste removal from waterLiliana Giraldo0Carlos A. Guerrero Fajardo1Juan Carlos Moreno Piraján2Departamento de Química, Grupo de Calorimetría, Universidad Nacional de Colombia, Sede Bogotá, Bogotá DC 11001, ColombiaDepartamento de Química, Facultad de Ciencias, Grupo Aprena, Universidad Nacional de Colombia, Sede Bogotá, Bogotá DC 11001, ColombiaDepartamento de Química, Facultad de Ciencias, Grupo de Investigación en Sólidos Porosos y Calorimetría, Universidad de los Andes, Carrera 1 No. 18 A-12, Bogotá DC 111711, Colombia; Corresponding author.The study explores the adsorption behavior of pharmaceutical molecules, including the antiepileptic drug Levetiracetam (LEV), Ketorolac Tromethamine (KT), and Mefenamic Acid (MA), using bioadsorbents based on chitosan and graphene derivatives. Chitosan, derived from crab shell chitin, was blended with graphene oxide (GO) and reduced graphene oxide (rGO) at varying concentrations (0.05 % and 0.5 %) to assess its impact on adsorption performance and material properties. Composites containing 0.5 % GO and rGO demonstrated the highest adsorption capacities, achieving maximum values of 30.85mg/g for KT on rGO and 29.74mg/g on GO. Adsorption equilibrium was rapidly attained, typically within 10 min to a few hours, and the process conformed to a pseudo-second-order kinetic model. Adsorption isotherms were best described by the Sips model, suggesting increased capacity with rising temperature, consistent with results from immersion calorimetry. Optimal adsorption occurred at a pH of 5.5 and a temperature of 60 °C. Comprehensive characterization using N2 and CO2 adsorption isotherms, FTIR, Raman spectroscopy, and pHpzc measurements validated the physical and chemical properties of the adsorbents. Thermodynamic analyses revealed spontaneous and exothermic adsorption interactions, with enthalpy values indicative of physical adsorption mechanisms. These findings underscore the potential of these chitosan-based bioadsorbents for the efficient removal of pharmaceutical molecules, demonstrating their applicability in environmental remediation and water purification technologies.http://www.sciencedirect.com/science/article/pii/S2590123024019406Adsorption isothermsAntiepilepticsChitosanGraphene oxideImmersion calorimetryThermodynamic |
| spellingShingle | Liliana Giraldo Carlos A. Guerrero Fajardo Juan Carlos Moreno Piraján Innovative chitosan/graphene oxide composites: A thermodynamic and calorimetric approach to pharmaceutical waste removal from water Results in Engineering Adsorption isotherms Antiepileptics Chitosan Graphene oxide Immersion calorimetry Thermodynamic |
| title | Innovative chitosan/graphene oxide composites: A thermodynamic and calorimetric approach to pharmaceutical waste removal from water |
| title_full | Innovative chitosan/graphene oxide composites: A thermodynamic and calorimetric approach to pharmaceutical waste removal from water |
| title_fullStr | Innovative chitosan/graphene oxide composites: A thermodynamic and calorimetric approach to pharmaceutical waste removal from water |
| title_full_unstemmed | Innovative chitosan/graphene oxide composites: A thermodynamic and calorimetric approach to pharmaceutical waste removal from water |
| title_short | Innovative chitosan/graphene oxide composites: A thermodynamic and calorimetric approach to pharmaceutical waste removal from water |
| title_sort | innovative chitosan graphene oxide composites a thermodynamic and calorimetric approach to pharmaceutical waste removal from water |
| topic | Adsorption isotherms Antiepileptics Chitosan Graphene oxide Immersion calorimetry Thermodynamic |
| url | http://www.sciencedirect.com/science/article/pii/S2590123024019406 |
| work_keys_str_mv | AT lilianagiraldo innovativechitosangrapheneoxidecompositesathermodynamicandcalorimetricapproachtopharmaceuticalwasteremovalfromwater AT carlosaguerrerofajardo innovativechitosangrapheneoxidecompositesathermodynamicandcalorimetricapproachtopharmaceuticalwasteremovalfromwater AT juancarlosmorenopirajan innovativechitosangrapheneoxidecompositesathermodynamicandcalorimetricapproachtopharmaceuticalwasteremovalfromwater |