Understanding tumour growth variability in breast cancer xenograft models identifies PARP inhibition resistance biomarkers

Understanding tumour growth variability in breast cancer xenograft models identifies PARP inhibition resistance biomarkers

Abstract Understanding the mechanisms of resistance to PARP inhibitors (PARPi) is a clinical priority, especially in breast cancer. We developed a novel mathematical framework accounting for intrinsic resistance to olaparib, identified by fitting the model to tumour growth metrics from breast cancer...

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Main Authors: D. Voulgarelis, J. V. Forment, A. Herencia Ropero, D. Polychronopoulos, J. Cohen-Setton, A. Bender, V. Serra, M. J. O’Connor, J. W. T. Yates, K. C. Bulusu
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-024-00702-x
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