Timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with Levothyroxine
Abstract Background Children with congenital hypothyroidism (CH) are at increased risk of developing childhood obesity. Moreover, an adiposity rebound (AR) that occur early is strongly linked with future obesity. The aims of our study were to explore the timing of AR, to identify factors affecting A...
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BMC
2025-08-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | https://doi.org/10.1186/s13052-025-02099-0 |
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| author | Cecilia Lugarà Domenico Corica Giorgia Pepe Maria Francesca Messina Mariella Valenzise Giuseppina Zirilli Letteria Anna Morabito Alessandra Li Pomi Malgorzata Gabriela Wasniewska Tommaso Aversa |
| author_facet | Cecilia Lugarà Domenico Corica Giorgia Pepe Maria Francesca Messina Mariella Valenzise Giuseppina Zirilli Letteria Anna Morabito Alessandra Li Pomi Malgorzata Gabriela Wasniewska Tommaso Aversa |
| author_sort | Cecilia Lugarà |
| collection | DOAJ |
| description | Abstract Background Children with congenital hypothyroidism (CH) are at increased risk of developing childhood obesity. Moreover, an adiposity rebound (AR) that occur early is strongly linked with future obesity. The aims of our study were to explore the timing of AR, to identify factors affecting AR and correlation between age and body mass index (BMI) at AR and BMI at eight years of age in children with CH. Methods A retrospective, observational study was conducted on Caucasian children with CH. For each child, BMI growth curve was constructed, AR was identified and compared with the Italian national and regional references. Results Sixty-nine patients (44 females) were recruited. The age at AR was 3.4 ± 1.2 vs. 4.5 years of the comparison population (p < 0.001) in females and 3.4 ± 1.4 vs. 5.0 years of the comparison population (p < 0.001) in males with CH. Age at AR showed a significant negative correlation with BMI at 8 years (r = − 0.274, p < 0.039). BMI at AR and BMI at 8 years of age correlated positively (r = 0.460, p < 0.001). The prevalence of obesity/overweight at 8 years of age was 30%. BMI at 8 years of age was 22.4 ± 1.8 kg/m2 in overweight/obese subgroup and 16.9 ± 1.8 kg/m2 in normal BMI subgroup (P 0.001). Conclusion Children with CH showed earlier AR compared to Italian national references. The higher risk of obesity in patients with early AR is supported by the association between age, BMI at AR, and BMI at eight years. |
| format | Article |
| id | doaj-art-7be6f23da4bb47d8a9d1645002ff0ff8 |
| institution | Kabale University |
| issn | 1824-7288 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj-art-7be6f23da4bb47d8a9d1645002ff0ff82025-08-20T03:46:28ZengBMCItalian Journal of Pediatrics1824-72882025-08-0151111010.1186/s13052-025-02099-0Timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with LevothyroxineCecilia Lugarà0Domenico Corica1Giorgia Pepe2Maria Francesca Messina3Mariella Valenzise4Giuseppina Zirilli5Letteria Anna Morabito6Alessandra Li Pomi7Malgorzata Gabriela Wasniewska8Tommaso Aversa9Department of Human Pathology of Adulthood and Childhood, University of MessinaDepartment of Human Pathology of Adulthood and Childhood, University of MessinaDepartment of Human Pathology of Adulthood and Childhood, University of MessinaDepartment of Human Pathology of Adulthood and Childhood, University of MessinaDepartment of Human Pathology of Adulthood and Childhood, University of MessinaDepartment of Human Pathology of Adulthood and Childhood, University of MessinaPediatric Unit, “G. Martino” University HospitalDepartment of Human Pathology of Adulthood and Childhood, University of MessinaDepartment of Human Pathology of Adulthood and Childhood, University of MessinaDepartment of Human Pathology of Adulthood and Childhood, University of MessinaAbstract Background Children with congenital hypothyroidism (CH) are at increased risk of developing childhood obesity. Moreover, an adiposity rebound (AR) that occur early is strongly linked with future obesity. The aims of our study were to explore the timing of AR, to identify factors affecting AR and correlation between age and body mass index (BMI) at AR and BMI at eight years of age in children with CH. Methods A retrospective, observational study was conducted on Caucasian children with CH. For each child, BMI growth curve was constructed, AR was identified and compared with the Italian national and regional references. Results Sixty-nine patients (44 females) were recruited. The age at AR was 3.4 ± 1.2 vs. 4.5 years of the comparison population (p < 0.001) in females and 3.4 ± 1.4 vs. 5.0 years of the comparison population (p < 0.001) in males with CH. Age at AR showed a significant negative correlation with BMI at 8 years (r = − 0.274, p < 0.039). BMI at AR and BMI at 8 years of age correlated positively (r = 0.460, p < 0.001). The prevalence of obesity/overweight at 8 years of age was 30%. BMI at 8 years of age was 22.4 ± 1.8 kg/m2 in overweight/obese subgroup and 16.9 ± 1.8 kg/m2 in normal BMI subgroup (P 0.001). Conclusion Children with CH showed earlier AR compared to Italian national references. The higher risk of obesity in patients with early AR is supported by the association between age, BMI at AR, and BMI at eight years.https://doi.org/10.1186/s13052-025-02099-0Congenital hypothyroidismNeonatal screeningLevothyroxineAdiposity reboundEarly adiposity reboundChildhood obesity |
| spellingShingle | Cecilia Lugarà Domenico Corica Giorgia Pepe Maria Francesca Messina Mariella Valenzise Giuseppina Zirilli Letteria Anna Morabito Alessandra Li Pomi Malgorzata Gabriela Wasniewska Tommaso Aversa Timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with Levothyroxine Italian Journal of Pediatrics Congenital hypothyroidism Neonatal screening Levothyroxine Adiposity rebound Early adiposity rebound Childhood obesity |
| title | Timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with Levothyroxine |
| title_full | Timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with Levothyroxine |
| title_fullStr | Timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with Levothyroxine |
| title_full_unstemmed | Timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with Levothyroxine |
| title_short | Timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with Levothyroxine |
| title_sort | timing of adiposity rebound in children with congenital hypothyroidism diagnosed by newborn screening and treated with levothyroxine |
| topic | Congenital hypothyroidism Neonatal screening Levothyroxine Adiposity rebound Early adiposity rebound Childhood obesity |
| url | https://doi.org/10.1186/s13052-025-02099-0 |
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