Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumor
Background: The incidence of brain tumors poses a significant threat, particularly with high-grade tumors that exhibit rapid growth and can significantly impair the patient's quality of life, despite treatment modalities. Ayurveda, a natural system of medicines helps to enhance health benefits...
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Elsevier
2024-09-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947624001852 |
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| author | Sadanand Sardeshmukh Vineeta Deshmukh Arvind Kulkarni Swapna Kulkarni Vasanti Godse Shrinivas Datar Sushama Bhuvad Shweta Gujar Sameer Gore Bhagyashree Sardeshmukh Vinita Awalkanthe Anita Shingte Sneha Dalvi Vijay Radye Sandeep Chavan |
| author_facet | Sadanand Sardeshmukh Vineeta Deshmukh Arvind Kulkarni Swapna Kulkarni Vasanti Godse Shrinivas Datar Sushama Bhuvad Shweta Gujar Sameer Gore Bhagyashree Sardeshmukh Vinita Awalkanthe Anita Shingte Sneha Dalvi Vijay Radye Sandeep Chavan |
| author_sort | Sadanand Sardeshmukh |
| collection | DOAJ |
| description | Background: The incidence of brain tumors poses a significant threat, particularly with high-grade tumors that exhibit rapid growth and can significantly impair the patient's quality of life, despite treatment modalities. Ayurveda, a natural system of medicines helps to enhance health benefits when used as a complementary therapy in combination with conventional treatment through various herbal, herbo-mineral or herbo-mineral-metallic formulations. One of such formulations, Raupya Suvarna Sutshekhara (RSS), has Raupya bhasma and Suvarna bhasma (incinerated Silver and Gold respectively) ingredients and they are described as Rasayana (immunomodulatory) and possess Medhya (enhances the brain functions and intelligence) activity. Objective: The study documents effects of Raupya Suvarna Sutshekhara in alleviating symptoms of malignant brain tumors. Materials and methods: This retrospective cohort study was done for malignant brain tumor patients (n = 110) registered at our centre who were treated with Raupya Suvarna Sutshekhara 125 mg–250 mg (a herbo-mineral metallic formulation) as a treatment of choice of neural tonic along with supporting Ayurvedic medicines. Treatment response evaluation period ranged from 3 months to 5 years (median period 29 weeks). Clinical symptoms, weight, Karnofsky Performance Score (KPS), Quality of Life (QoL) score, and survival data with respect to treatment with RSS were analyzed. Results: RSS showed a very significant (p < 0.001) effect on symptoms related to memory loss, headache, imbalance, loss of appetite, and generalized weakness while significant (p < 0.05) decrease in urinary incontinence, seizures, difficulty in thinking/articulating, and weakness in one part/side of the body. However, a not-quite significant change was seen in symptom confusion/disorientation. No significant improvement was seen in vision changes, facial numbness or tingling, swallowing difficulties, and tingling in extremities. Body weight and KPS also showed improvement. Patients with treatment between 2 and 5 years showed median survival up to 62 months. Conclusions: It was observed that adjunct Ayurvedic treatment with RSS helped to reduce the severity of symptoms due to the tumor itself or side-effects of conventional treatments, maintain the quality of life of malignant brain tumor patients and has shown to increase survival with respect to the duration of the treatment. |
| format | Article |
| id | doaj-art-7bd5ce3d972548e6a92ba73f7e6f6f92 |
| institution | Kabale University |
| issn | 0975-9476 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj-art-7bd5ce3d972548e6a92ba73f7e6f6f922024-11-10T04:07:45ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762024-09-01155101070Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumorSadanand Sardeshmukh0Vineeta Deshmukh1Arvind Kulkarni2Swapna Kulkarni3Vasanti Godse4Shrinivas Datar5Sushama Bhuvad6Shweta Gujar7Sameer Gore8Bhagyashree Sardeshmukh9Vinita Awalkanthe10Anita Shingte11Sneha Dalvi12Vijay Radye13Sandeep Chavan14Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaCorresponding author. Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Kesnand Road, Wagholi, Pune, 412207, Maharashtra, India.; Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, Maharashtra, IndiaBackground: The incidence of brain tumors poses a significant threat, particularly with high-grade tumors that exhibit rapid growth and can significantly impair the patient's quality of life, despite treatment modalities. Ayurveda, a natural system of medicines helps to enhance health benefits when used as a complementary therapy in combination with conventional treatment through various herbal, herbo-mineral or herbo-mineral-metallic formulations. One of such formulations, Raupya Suvarna Sutshekhara (RSS), has Raupya bhasma and Suvarna bhasma (incinerated Silver and Gold respectively) ingredients and they are described as Rasayana (immunomodulatory) and possess Medhya (enhances the brain functions and intelligence) activity. Objective: The study documents effects of Raupya Suvarna Sutshekhara in alleviating symptoms of malignant brain tumors. Materials and methods: This retrospective cohort study was done for malignant brain tumor patients (n = 110) registered at our centre who were treated with Raupya Suvarna Sutshekhara 125 mg–250 mg (a herbo-mineral metallic formulation) as a treatment of choice of neural tonic along with supporting Ayurvedic medicines. Treatment response evaluation period ranged from 3 months to 5 years (median period 29 weeks). Clinical symptoms, weight, Karnofsky Performance Score (KPS), Quality of Life (QoL) score, and survival data with respect to treatment with RSS were analyzed. Results: RSS showed a very significant (p < 0.001) effect on symptoms related to memory loss, headache, imbalance, loss of appetite, and generalized weakness while significant (p < 0.05) decrease in urinary incontinence, seizures, difficulty in thinking/articulating, and weakness in one part/side of the body. However, a not-quite significant change was seen in symptom confusion/disorientation. No significant improvement was seen in vision changes, facial numbness or tingling, swallowing difficulties, and tingling in extremities. Body weight and KPS also showed improvement. Patients with treatment between 2 and 5 years showed median survival up to 62 months. Conclusions: It was observed that adjunct Ayurvedic treatment with RSS helped to reduce the severity of symptoms due to the tumor itself or side-effects of conventional treatments, maintain the quality of life of malignant brain tumor patients and has shown to increase survival with respect to the duration of the treatment.http://www.sciencedirect.com/science/article/pii/S0975947624001852Primary brain tumorsRaupya Suvarna SutshekharaIncinerated silverIncinerated goldSurvival analysis |
| spellingShingle | Sadanand Sardeshmukh Vineeta Deshmukh Arvind Kulkarni Swapna Kulkarni Vasanti Godse Shrinivas Datar Sushama Bhuvad Shweta Gujar Sameer Gore Bhagyashree Sardeshmukh Vinita Awalkanthe Anita Shingte Sneha Dalvi Vijay Radye Sandeep Chavan Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumor Journal of Ayurveda and Integrative Medicine Primary brain tumors Raupya Suvarna Sutshekhara Incinerated silver Incinerated gold Survival analysis |
| title | Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumor |
| title_full | Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumor |
| title_fullStr | Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumor |
| title_full_unstemmed | Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumor |
| title_short | Effects of Raupya Suvarna Sutashekhara, a herbo-mineral-metallic formulation as adjunct Oral Ayurvedic Medicine on long-term survival in patients of malignant brain tumor |
| title_sort | effects of raupya suvarna sutashekhara a herbo mineral metallic formulation as adjunct oral ayurvedic medicine on long term survival in patients of malignant brain tumor |
| topic | Primary brain tumors Raupya Suvarna Sutshekhara Incinerated silver Incinerated gold Survival analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0975947624001852 |
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