Functional hydrogel empowering 3D printing titanium alloys
Titanium alloys are widely used in the manufacture of orthopedic prosthesis given their excellent mechanical properties and biocompatibility. However, the primary drawbacks of traditional titanium alloy prosthesis are their much higher elastic modulus than cancellous bone and poor interfacial adhesi...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004836 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841533244341747712 |
|---|---|
| author | Weimin Zhang Jiaxin Zhang He Liu Yang Liu Xiao Sheng Sixing Zhou Tiansen Pei Chen Li Jincheng Wang |
| author_facet | Weimin Zhang Jiaxin Zhang He Liu Yang Liu Xiao Sheng Sixing Zhou Tiansen Pei Chen Li Jincheng Wang |
| author_sort | Weimin Zhang |
| collection | DOAJ |
| description | Titanium alloys are widely used in the manufacture of orthopedic prosthesis given their excellent mechanical properties and biocompatibility. However, the primary drawbacks of traditional titanium alloy prosthesis are their much higher elastic modulus than cancellous bone and poor interfacial adhesion, which lead to poor osseointegration. 3D-printed porous titanium alloys can partly address these issues, but their bio-inertness still requires modifications to adapt to different physiological and pathological microenvironments. Hydrogels composed of three-dimensional networks of hydrophilic polymers can effectively simulate the extracellular matrix of natural bone and are capable of loading bioactive molecules such as proteins, peptides, growths factors, polysaccharides, or nucleotides for localized release within the human body, by directly participating in biological processes. Combining 3D-printed porous titanium alloys with hydrogels to construct a bioactive composite system that regulates cellular adhesion, proliferation, migration, and differentiation in the local microenvironment is of great significance for enhancing the bioactivity of the prosthesis surface. In this review, we focus on three aspects of the bioactive composite system: (Ⅰ) strategies for constructing bioactive interfaces with hydrogels, and (Ⅱ) how bioactive composite systems regulate the microenvironment under different physiological and pathological conditions to enhance the osteointegration and bone regeneration capability of prostheses. Considering the current research status in this field, innovations in orthopedic prosthesis can be achieved through material optimization, personalized customization, and the development of multifunctional composite systems. These advancements provide essential references for the clinical translation of osseointegration and bone regeneration in various physiological and pathological microenvironments. |
| format | Article |
| id | doaj-art-7bcf4bb34b744fe09328fc5d5db124f0 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-7bcf4bb34b744fe09328fc5d5db124f02025-01-17T04:52:10ZengElsevierMaterials Today Bio2590-00642025-02-0130101422Functional hydrogel empowering 3D printing titanium alloysWeimin Zhang0Jiaxin Zhang1He Liu2Yang Liu3Xiao Sheng4Sixing Zhou5Tiansen Pei6Chen Li7Jincheng Wang8Department of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China; Huzhou Central Hospital, Fifth school of Clinical Medical Universtiy, Wuxing, Huzhou, Zhejiang 313000, PR China; Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China; Huzhou Central Hospital, Fifth school of Clinical Medical Universtiy, Wuxing, Huzhou, Zhejiang 313000, PR China; Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China; Huzhou Central Hospital, Fifth school of Clinical Medical Universtiy, Wuxing, Huzhou, Zhejiang 313000, PR China; Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China; Huzhou Central Hospital, Fifth school of Clinical Medical Universtiy, Wuxing, Huzhou, Zhejiang 313000, PR China; Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China; Huzhou Central Hospital, Fifth school of Clinical Medical Universtiy, Wuxing, Huzhou, Zhejiang 313000, PR China; Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China; Huzhou Central Hospital, Fifth school of Clinical Medical Universtiy, Wuxing, Huzhou, Zhejiang 313000, PR China; Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China; Huzhou Central Hospital, Fifth school of Clinical Medical Universtiy, Wuxing, Huzhou, Zhejiang 313000, PR China; Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun 130041, ChinaCorresponding author.; Department of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China; Huzhou Central Hospital, Fifth school of Clinical Medical Universtiy, Wuxing, Huzhou, Zhejiang 313000, PR China; Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun 130041, ChinaDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China; Huzhou Central Hospital, Fifth school of Clinical Medical Universtiy, Wuxing, Huzhou, Zhejiang 313000, PR China; Department of Emergency and Critical Care Medicine, The Second Hospital of Jilin University, Changchun 130041, ChinaTitanium alloys are widely used in the manufacture of orthopedic prosthesis given their excellent mechanical properties and biocompatibility. However, the primary drawbacks of traditional titanium alloy prosthesis are their much higher elastic modulus than cancellous bone and poor interfacial adhesion, which lead to poor osseointegration. 3D-printed porous titanium alloys can partly address these issues, but their bio-inertness still requires modifications to adapt to different physiological and pathological microenvironments. Hydrogels composed of three-dimensional networks of hydrophilic polymers can effectively simulate the extracellular matrix of natural bone and are capable of loading bioactive molecules such as proteins, peptides, growths factors, polysaccharides, or nucleotides for localized release within the human body, by directly participating in biological processes. Combining 3D-printed porous titanium alloys with hydrogels to construct a bioactive composite system that regulates cellular adhesion, proliferation, migration, and differentiation in the local microenvironment is of great significance for enhancing the bioactivity of the prosthesis surface. In this review, we focus on three aspects of the bioactive composite system: (Ⅰ) strategies for constructing bioactive interfaces with hydrogels, and (Ⅱ) how bioactive composite systems regulate the microenvironment under different physiological and pathological conditions to enhance the osteointegration and bone regeneration capability of prostheses. Considering the current research status in this field, innovations in orthopedic prosthesis can be achieved through material optimization, personalized customization, and the development of multifunctional composite systems. These advancements provide essential references for the clinical translation of osseointegration and bone regeneration in various physiological and pathological microenvironments.http://www.sciencedirect.com/science/article/pii/S2590006424004836Porous titanium alloyFunctionalized hydrogelLocal microenvironmentOsseointegrationDrug delivery |
| spellingShingle | Weimin Zhang Jiaxin Zhang He Liu Yang Liu Xiao Sheng Sixing Zhou Tiansen Pei Chen Li Jincheng Wang Functional hydrogel empowering 3D printing titanium alloys Materials Today Bio Porous titanium alloy Functionalized hydrogel Local microenvironment Osseointegration Drug delivery |
| title | Functional hydrogel empowering 3D printing titanium alloys |
| title_full | Functional hydrogel empowering 3D printing titanium alloys |
| title_fullStr | Functional hydrogel empowering 3D printing titanium alloys |
| title_full_unstemmed | Functional hydrogel empowering 3D printing titanium alloys |
| title_short | Functional hydrogel empowering 3D printing titanium alloys |
| title_sort | functional hydrogel empowering 3d printing titanium alloys |
| topic | Porous titanium alloy Functionalized hydrogel Local microenvironment Osseointegration Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004836 |
| work_keys_str_mv | AT weiminzhang functionalhydrogelempowering3dprintingtitaniumalloys AT jiaxinzhang functionalhydrogelempowering3dprintingtitaniumalloys AT heliu functionalhydrogelempowering3dprintingtitaniumalloys AT yangliu functionalhydrogelempowering3dprintingtitaniumalloys AT xiaosheng functionalhydrogelempowering3dprintingtitaniumalloys AT sixingzhou functionalhydrogelempowering3dprintingtitaniumalloys AT tiansenpei functionalhydrogelempowering3dprintingtitaniumalloys AT chenli functionalhydrogelempowering3dprintingtitaniumalloys AT jinchengwang functionalhydrogelempowering3dprintingtitaniumalloys |