The roles of regulatory-compliant media and inflammatory/oxytocin priming selection in enhancing human mesenchymal stem/stromal cell immunomodulatory properties

The roles of regulatory-compliant media and inflammatory/oxytocin priming selection in enhancing human mesenchymal stem/stromal cell immunomodulatory properties

Abstract Osteoarthritis (OA) represents a significant global health burden without a known disease modifying agent thereby necessitating pursuit of innovative therapeutic approaches. The infrapatellar fat pad (IFP) serves as a reservoir of mesenchymal stem/stromal cells (MSC), and with adjacent syno...

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Bibliographic Details
Main Authors: Mahammad Gardashli, Max Baron, Philip Drohat, Daniel Quintero, Lee D. Kaplan, Angela Szeto, Armando J. Mendez, Thomas M. Best, Dimitrios Kouroupis
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Mesenchymal stem/stromal cells
Growth medium
Immunomodulation
Inflammatory priming
Oxytocin priming
Osteoarthritis
Online Access:https://doi.org/10.1038/s41598-024-80050-9
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