Blinatumomab use in pediatric B-ALL: where are we now?
Abstract: Blinatumomab, a bispecific T-cell–engager antibody construct targeting CD19, has emerged as a transformative therapy in B-cell acute lymphoblastic leukemia (B-ALL) in both adult and pediatric populations. In pediatric populations, blinatumomab has demonstrated efficacy both in patients wit...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | Blood Advances |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2473952925003210 |
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| _version_ | 1849247598757543936 |
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| author | Anurekha G. Hall Rachel E. Rau |
| author_facet | Anurekha G. Hall Rachel E. Rau |
| author_sort | Anurekha G. Hall |
| collection | DOAJ |
| description | Abstract: Blinatumomab, a bispecific T-cell–engager antibody construct targeting CD19, has emerged as a transformative therapy in B-cell acute lymphoblastic leukemia (B-ALL) in both adult and pediatric populations. In pediatric populations, blinatumomab has demonstrated efficacy both in patients with relapsed or refractory disease and as a component of frontline therapy for newly diagnosed patients. In this review, we discuss the trials that led to regulatory approvals of blinatumomab, with an emphasis on its application in pediatric patients. We will also examine the use of blinatumomab in special populations, explore ongoing questions surrounding its role in the treatment of B-ALL, and highlight key considerations for future clinical use. |
| format | Article |
| id | doaj-art-7bb66eff816a4e70ab05a6c33a9a19bb |
| institution | Kabale University |
| issn | 2473-9529 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Blood Advances |
| spelling | doaj-art-7bb66eff816a4e70ab05a6c33a9a19bb2025-08-20T03:58:10ZengElsevierBlood Advances2473-95292025-08-019153946395410.1182/bloodadvances.2024014043Blinatumomab use in pediatric B-ALL: where are we now?Anurekha G. Hall0Rachel E. Rau1Department of Pediatric Hematology/Oncology, Seattle Children’s Hospital, University of Washington, Seattle, WA; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle, WADepartment of Pediatric Hematology/Oncology, Seattle Children’s Hospital, University of Washington, Seattle, WA; Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle, WA; Correspondence: Rachel E. Rau, Department of Pediatric Hematology/Oncology, University of Washington/Seattle Children’s Hospital, 4800 Sand Point Way NE, Seattle, WA 98105;Abstract: Blinatumomab, a bispecific T-cell–engager antibody construct targeting CD19, has emerged as a transformative therapy in B-cell acute lymphoblastic leukemia (B-ALL) in both adult and pediatric populations. In pediatric populations, blinatumomab has demonstrated efficacy both in patients with relapsed or refractory disease and as a component of frontline therapy for newly diagnosed patients. In this review, we discuss the trials that led to regulatory approvals of blinatumomab, with an emphasis on its application in pediatric patients. We will also examine the use of blinatumomab in special populations, explore ongoing questions surrounding its role in the treatment of B-ALL, and highlight key considerations for future clinical use.http://www.sciencedirect.com/science/article/pii/S2473952925003210 |
| spellingShingle | Anurekha G. Hall Rachel E. Rau Blinatumomab use in pediatric B-ALL: where are we now? Blood Advances |
| title | Blinatumomab use in pediatric B-ALL: where are we now? |
| title_full | Blinatumomab use in pediatric B-ALL: where are we now? |
| title_fullStr | Blinatumomab use in pediatric B-ALL: where are we now? |
| title_full_unstemmed | Blinatumomab use in pediatric B-ALL: where are we now? |
| title_short | Blinatumomab use in pediatric B-ALL: where are we now? |
| title_sort | blinatumomab use in pediatric b all where are we now |
| url | http://www.sciencedirect.com/science/article/pii/S2473952925003210 |
| work_keys_str_mv | AT anurekhaghall blinatumomabuseinpediatricballwherearewenow AT rachelerau blinatumomabuseinpediatricballwherearewenow |