Advancements and challenges in CAR-T cell therapy for solid tumors: A comprehensive review of antigen targets, strategies, and future directions

Advancements and challenges in CAR-T cell therapy for solid tumors: A comprehensive review of antigen targets, strategies, and future directions

Abstract Chimeric antigen receptor-modified T cell therapy, originally employed in hematological malignancies treatment, has made significant strides in addressing solid tumors in recent years. Presently, second-generation CAR-T therapy has reached clinical implementation, while fifth-generation CAR...

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Main Authors: Jiajun Zhu, Jianming Zhou, Yiting Tang, Ruotong Huang, Chengjia Lu, Ke Qian, Qingyu Zhou, Jingjun Zhang, Xiaoyi Yang, Wenhan Zhou, Jiaqiang Wu, Qiudan Chen, Yong Lin, Shuying Chen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cancer Cell International
Subjects:
CAR-T
Solid tumor
Immunotherapy
Antigen target
Personalized treatment
Online Access:https://doi.org/10.1186/s12935-025-03938-0
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https://doi.org/10.1186/s12935-025-03938-0

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