Paracetamol metabolism by endothelial cells – Potential mechanism underlying intravenous paracetamol-induced hypotension

Paracetamol metabolism by endothelial cells – Potential mechanism underlying intravenous paracetamol-induced hypotension

It was shown previously that a metabolite of acetaminophen (APAP), N-acetyl-p-benzoquinone imine (NAPQI), is a potent vasodilator, which could underlie the hypotension observed when APAP is administered intravenously. However, it is unknown whether APAP metabolism to NAPQI is possible in the vascula...

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Bibliographic Details
Main Authors: Johs Dannesboe, Joakim A. Bastrup, Kathrine Holm Nielsen, Pelle Munck, Morten B. Thomsen, Clare L. Hawkins, Thomas A. Jepps
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Pharmacological Research
Subjects:
Acetaminophen
Paracetamol
NAPQI
Myeloperoxidase
Endothelium
CYP20A1
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004857
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