Three musketeers of PDA-based MRI contrasting and therapy
Polydopamine (PDA) stands as a versatile material explored in cancer nanomedicine for its unique properties, offering opportunities for multifunctional drug delivery platforms. This study explores the potential of utilizing a one-pot synthesis to concurrently integrate Fe, Gd and Mn ions into porous...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2024.2356773 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846139342126317568 |
|---|---|
| author | Magdalena J. Bigaj-Józefowska Tomasz Zalewski Karol Załęski Emerson Coy Marcin Frankowski Radosław Mrówczyński Bartosz F. Grześkowiak |
| author_facet | Magdalena J. Bigaj-Józefowska Tomasz Zalewski Karol Załęski Emerson Coy Marcin Frankowski Radosław Mrówczyński Bartosz F. Grześkowiak |
| author_sort | Magdalena J. Bigaj-Józefowska |
| collection | DOAJ |
| description | Polydopamine (PDA) stands as a versatile material explored in cancer nanomedicine for its unique properties, offering opportunities for multifunctional drug delivery platforms. This study explores the potential of utilizing a one-pot synthesis to concurrently integrate Fe, Gd and Mn ions into porous PDA-based theranostic drug delivery platforms called Ferritis, Gadolinis and Manganis, respectively. Our investigation spans the morphology, magnetic properties, photothermal characteristics and cytotoxicity profiles of those potent nanoformulations. The obtained structures showcase a spherical morphology, robust magnetic response and promising photothermal behaviour. All of the presented nanoparticles (NPs) display pronounced paramagnetism, revealing contrasting potential for MRI imaging. Relaxivity values, a key determinant of contrast efficacy, demonstrated competitive or superior performance compared to established, used contrasting agents. These nanoformulations also exhibited robust photothermal properties under near infra-red irradiation, showcasing their possible application for photothermal therapy of cancer. Our findings provide insights into the potential of metal-doped PDA NPs for cancer theranostics. |
| format | Article |
| id | doaj-art-7b79ca229108419195a0d2bd27dcadac |
| institution | Kabale University |
| issn | 2169-1401 2169-141X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj-art-7b79ca229108419195a0d2bd27dcadac2024-12-06T10:48:00ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2024-12-0152132133310.1080/21691401.2024.2356773Three musketeers of PDA-based MRI contrasting and therapyMagdalena J. Bigaj-Józefowska0Tomasz Zalewski1Karol Załęski2Emerson Coy3Marcin Frankowski4Radosław Mrówczyński5Bartosz F. Grześkowiak6NanoBioMedical Centre, Adam Mickiewicz University in Poznań, Poznań, PolandNanoBioMedical Centre, Adam Mickiewicz University in Poznań, Poznań, PolandNanoBioMedical Centre, Adam Mickiewicz University in Poznań, Poznań, PolandNanoBioMedical Centre, Adam Mickiewicz University in Poznań, Poznań, PolandFaculty of Chemistry, Adam Mickiewicz University in Poznań, Poznań, PolandFaculty of Chemistry, Adam Mickiewicz University in Poznań, Poznań, PolandNanoBioMedical Centre, Adam Mickiewicz University in Poznań, Poznań, PolandPolydopamine (PDA) stands as a versatile material explored in cancer nanomedicine for its unique properties, offering opportunities for multifunctional drug delivery platforms. This study explores the potential of utilizing a one-pot synthesis to concurrently integrate Fe, Gd and Mn ions into porous PDA-based theranostic drug delivery platforms called Ferritis, Gadolinis and Manganis, respectively. Our investigation spans the morphology, magnetic properties, photothermal characteristics and cytotoxicity profiles of those potent nanoformulations. The obtained structures showcase a spherical morphology, robust magnetic response and promising photothermal behaviour. All of the presented nanoparticles (NPs) display pronounced paramagnetism, revealing contrasting potential for MRI imaging. Relaxivity values, a key determinant of contrast efficacy, demonstrated competitive or superior performance compared to established, used contrasting agents. These nanoformulations also exhibited robust photothermal properties under near infra-red irradiation, showcasing their possible application for photothermal therapy of cancer. Our findings provide insights into the potential of metal-doped PDA NPs for cancer theranostics.https://www.tandfonline.com/doi/10.1080/21691401.2024.2356773Polydopamine nanoparticlesmagnetic resonance imagingphotothermal therapytheranosticscancer diagnostics |
| spellingShingle | Magdalena J. Bigaj-Józefowska Tomasz Zalewski Karol Załęski Emerson Coy Marcin Frankowski Radosław Mrówczyński Bartosz F. Grześkowiak Three musketeers of PDA-based MRI contrasting and therapy Artificial Cells, Nanomedicine, and Biotechnology Polydopamine nanoparticles magnetic resonance imaging photothermal therapy theranostics cancer diagnostics |
| title | Three musketeers of PDA-based MRI contrasting and therapy |
| title_full | Three musketeers of PDA-based MRI contrasting and therapy |
| title_fullStr | Three musketeers of PDA-based MRI contrasting and therapy |
| title_full_unstemmed | Three musketeers of PDA-based MRI contrasting and therapy |
| title_short | Three musketeers of PDA-based MRI contrasting and therapy |
| title_sort | three musketeers of pda based mri contrasting and therapy |
| topic | Polydopamine nanoparticles magnetic resonance imaging photothermal therapy theranostics cancer diagnostics |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2024.2356773 |
| work_keys_str_mv | AT magdalenajbigajjozefowska threemusketeersofpdabasedmricontrastingandtherapy AT tomaszzalewski threemusketeersofpdabasedmricontrastingandtherapy AT karolzałeski threemusketeersofpdabasedmricontrastingandtherapy AT emersoncoy threemusketeersofpdabasedmricontrastingandtherapy AT marcinfrankowski threemusketeersofpdabasedmricontrastingandtherapy AT radosławmrowczynski threemusketeersofpdabasedmricontrastingandtherapy AT bartoszfgrzeskowiak threemusketeersofpdabasedmricontrastingandtherapy |