Tim-3 pathway dysregulation and targeting in sepsis-induced immunosuppression

Tim-3 pathway dysregulation and targeting in sepsis-induced immunosuppression

Abstract Sepsis is a major medical problem which causes millions of deaths worldwide every year. The host immune response in sepsis is characterized by acute inflammation and a simultaneous state of immunosuppression. In the later stage of sepsis, immunosuppression is a crucial factor that increases...

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Bibliographic Details
Main Authors: Jialiu Luo, Cong Zhang, Deng Chen, Teding Chang, Shunyao Chen, Zhiqiang Lin, Chengla Yi, Zhao-Hui Tang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:European Journal of Medical Research
Subjects:
Immune checkpoint
Tim-3
Sepsis
Immunosuppression
Online Access:https://doi.org/10.1186/s40001-024-02203-w
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