Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocol
Introduction Nausea and vomiting are two most common symptoms reported by children with cancer when they undergo active treatment. However, pharmacological treatment is not sufficient to manage these two symptoms, with over 40% of children still experience nausea and vomiting after receiving antieme...
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BMJ Publishing Group
2019-10-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/9/10/e031834.full |
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| author | Wei Xia Ka Yan Ho Katherine Ka Wai Lam Ho Cheung William LI Joyce Oi Kwan Chung Ankie Tan Cheung Long Kwan Ho Sau Ying Chiu Godfrey Chi Fung Chan |
| author_facet | Wei Xia Ka Yan Ho Katherine Ka Wai Lam Ho Cheung William LI Joyce Oi Kwan Chung Ankie Tan Cheung Long Kwan Ho Sau Ying Chiu Godfrey Chi Fung Chan |
| author_sort | Wei Xia |
| collection | DOAJ |
| description | Introduction Nausea and vomiting are two most common symptoms reported by children with cancer when they undergo active treatment. However, pharmacological treatment is not sufficient to manage these two symptoms, with over 40% of children still experience nausea and vomiting after receiving antiemetics. There has been an exponential growth of studies to demonstrate the effectiveness of different complementary complementary medicine (CAM) to control nausea and vomiting during cancer treatment. Appropriate application of CAM enhances the effectiveness of antiemetics, thus reducing the symptom burden on children as well as improving their general condition and quality of life during cancer treatment. Nevertheless, it remains unclear which CAM is the best approach to help children to prevent or reduce nausea and vomiting during and after cancer treatment. This paper describes a protocol for identifying, analysing and synthesising research evidence on the effectiveness of CAM on nausea and vomiting in children with cancer.Methods and analysis A total of 10 databases will be searched to identify appropriate literature: MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, CINAHL, PsycINFO, LILACS, OpenSIGLE, the Chinese Biomedical Literature Database, the Chinese Medical Current Contents and the Chinese National Knowledge Infrastructure. All randomised controlled trials which meet the inclusion criteria will be included. The primary outcome is the changes in nausea and vomiting either assessed by self-reported and/or objective measures. Review Manager 5.3 will be used to synthesise the data, calculate the treatment effects, perform any subgroup analysis and assess the risk of bias.Ethical and dissemination The results will be presented at international conferences and published in peer-reviewed journals. As no individual data will be involved in this review, ethical approval is not required.PROSPERO registration number CRD42019135404. |
| format | Article |
| id | doaj-art-7b63935e5f3f4ce19a0c9e36c903224c |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-7b63935e5f3f4ce19a0c9e36c903224c2024-12-12T22:05:14ZengBMJ Publishing GroupBMJ Open2044-60552019-10-0191010.1136/bmjopen-2019-031834Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocolWei Xia0Ka Yan Ho1Katherine Ka Wai Lam2Ho Cheung William LI3Joyce Oi Kwan Chung4Ankie Tan Cheung5Long Kwan Ho6Sau Ying Chiu7Godfrey Chi Fung Chan81 Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaSchool of Nursing, The Hong Kong Polytechnic University, Hong Kong, China1 School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China1 School of Nursing, The University of Hong Kong, Hong Kong, China1 School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China2 School of Nursing, The University of Hong Kong, Hong Kong, China2 School of Nursing, The University of Hong Kong, Hong Kong, China3 Department of Paediatrics & Adolescent Medicine, Hong Kong Children’s Hospital, Hong Kong, China4 Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong, ChinaIntroduction Nausea and vomiting are two most common symptoms reported by children with cancer when they undergo active treatment. However, pharmacological treatment is not sufficient to manage these two symptoms, with over 40% of children still experience nausea and vomiting after receiving antiemetics. There has been an exponential growth of studies to demonstrate the effectiveness of different complementary complementary medicine (CAM) to control nausea and vomiting during cancer treatment. Appropriate application of CAM enhances the effectiveness of antiemetics, thus reducing the symptom burden on children as well as improving their general condition and quality of life during cancer treatment. Nevertheless, it remains unclear which CAM is the best approach to help children to prevent or reduce nausea and vomiting during and after cancer treatment. This paper describes a protocol for identifying, analysing and synthesising research evidence on the effectiveness of CAM on nausea and vomiting in children with cancer.Methods and analysis A total of 10 databases will be searched to identify appropriate literature: MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), EMBASE, CINAHL, PsycINFO, LILACS, OpenSIGLE, the Chinese Biomedical Literature Database, the Chinese Medical Current Contents and the Chinese National Knowledge Infrastructure. All randomised controlled trials which meet the inclusion criteria will be included. The primary outcome is the changes in nausea and vomiting either assessed by self-reported and/or objective measures. Review Manager 5.3 will be used to synthesise the data, calculate the treatment effects, perform any subgroup analysis and assess the risk of bias.Ethical and dissemination The results will be presented at international conferences and published in peer-reviewed journals. As no individual data will be involved in this review, ethical approval is not required.PROSPERO registration number CRD42019135404.https://bmjopen.bmj.com/content/9/10/e031834.full |
| spellingShingle | Wei Xia Ka Yan Ho Katherine Ka Wai Lam Ho Cheung William LI Joyce Oi Kwan Chung Ankie Tan Cheung Long Kwan Ho Sau Ying Chiu Godfrey Chi Fung Chan Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocol BMJ Open |
| title | Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocol |
| title_full | Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocol |
| title_fullStr | Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocol |
| title_full_unstemmed | Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocol |
| title_short | Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocol |
| title_sort | systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer a study protocol |
| url | https://bmjopen.bmj.com/content/9/10/e031834.full |
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