Characterization and effective expansion of CD4−CD8− TCRαβ+ T cells from individuals living with type 1 diabetes

Characterization and effective expansion of CD4−CD8− TCRαβ+ T cells from individuals living with type 1 diabetes

CD4−CD8− TCRαβ+ (double-negative [DN]) T cells represent a rare T cell population that promotes immunological tolerance through various cytotoxic mechanisms. In mice, autologous transfer of DN T cells has shown protective effects against autoimmune diabetes and graft-versus-host disease. Here, we ch...

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Bibliographic Details
Main Authors: J. Ernesto Fajardo-Despaigne, Félix Lombard-Vadnais, Adam-Nicolas Pelletier, Aïnhoa Olazabal, Lucie Boutin, Sarah Pasquin, Valérie Janelle, Laurent Legault, Jean-Sébastien Delisle, Erin E. Hillhouse, Lise Coderre, Sylvie Lesage
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
DN T cells
unconventional T cell
cell therapy
type 1 diabetes
cellular expansion
tolerance
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012400216X
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