Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy?
BackgroundType 2 diabetes mellitus (T2DM) and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) are mutually causal, which can jointly promote the development of the disease. As an important means to evaluate the steatosis of MAFLD, Controlled Attenuation Parameter (CAP) can also evaluate...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1578371/full |
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| author | Jingsi Cao Tingting Bao Jingxian Cao Xuechun Fan Yanyan Wang Jing Yu Ying Wang RuiXue Deng Jingjing Shi Changlong Shen Qingwei Li Jia Mi |
| author_facet | Jingsi Cao Tingting Bao Jingxian Cao Xuechun Fan Yanyan Wang Jing Yu Ying Wang RuiXue Deng Jingjing Shi Changlong Shen Qingwei Li Jia Mi |
| author_sort | Jingsi Cao |
| collection | DOAJ |
| description | BackgroundType 2 diabetes mellitus (T2DM) and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) are mutually causal, which can jointly promote the development of the disease. As an important means to evaluate the steatosis of MAFLD, Controlled Attenuation Parameter (CAP) can also evaluate the metabolism related fat parameters. Whether Traditional Chinese Medicine preparation (TCM-preparation) can improve CAP has not been reported yet, so the purpose of this meta-analysis is to evaluate the effect of TCM-preparation on CAP in T2DM patients with MAFLD.MethodsIn this meta-analysis, eight databases were searched from the establishment of the database to 23 April 2025, to obtain clinical randomized controlled trials of TCM-preparation or TCM-preparation combined with Standard Biomedical Treatment in the treatment of T2DM complicated with MAFLD. After screening the literature and extracting the data, Meta-analysis was conducted using RevMan5.4 software, with results presented in the form of a forest plot. This study was registered with PROSPERO (CRD42024569613).ResultsA total of 599 papers were retrieved, and the papers were screened according to the nadir and ranking criteria, and finally 8 trials (648 participants) were included in this study. Meta-analysis showed that TCM-preparation significantly reduced CAP values in patients with T2DM combined with MAFLD compared with TCM-preparation (MD = −15.19, CI [−22.53, −7.85], P < 0.0001).ConclusionTCM-preparation can reduce the CAP value of T2DM combined with MAFLD and can have a good therapeutic effect on glucose-lipid metabolism level and liver function, indicating that TCM-preparation can reduce the deposition of hepatic fat, restore the function of hepatocytes, and have a positive effect on T2DM combined with MAFLD; however, due to the heterogeneity of the included literature, it needs to be further validation by high-quality trials. |
| format | Article |
| id | doaj-art-7b534dd5657f46efa9749b5cea96da4f |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-7b534dd5657f46efa9749b5cea96da4f2025-08-20T04:00:56ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-08-011610.3389/fphar.2025.15783711578371Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy?Jingsi Cao0Tingting Bao1Jingxian Cao2Xuechun Fan3Yanyan Wang4Jing Yu5Ying Wang6RuiXue Deng7Jingjing Shi8Changlong Shen9Qingwei Li10Jia Mi11College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaInstitute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaCollege of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan, ChinaCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaCollege of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, ChinaInstitute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGastroenterology department, Yanji/Yanbian Traditional Chinese Medicine Hospital, Yanji, ChinaInstitute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, ChinaBackgroundType 2 diabetes mellitus (T2DM) and Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) are mutually causal, which can jointly promote the development of the disease. As an important means to evaluate the steatosis of MAFLD, Controlled Attenuation Parameter (CAP) can also evaluate the metabolism related fat parameters. Whether Traditional Chinese Medicine preparation (TCM-preparation) can improve CAP has not been reported yet, so the purpose of this meta-analysis is to evaluate the effect of TCM-preparation on CAP in T2DM patients with MAFLD.MethodsIn this meta-analysis, eight databases were searched from the establishment of the database to 23 April 2025, to obtain clinical randomized controlled trials of TCM-preparation or TCM-preparation combined with Standard Biomedical Treatment in the treatment of T2DM complicated with MAFLD. After screening the literature and extracting the data, Meta-analysis was conducted using RevMan5.4 software, with results presented in the form of a forest plot. This study was registered with PROSPERO (CRD42024569613).ResultsA total of 599 papers were retrieved, and the papers were screened according to the nadir and ranking criteria, and finally 8 trials (648 participants) were included in this study. Meta-analysis showed that TCM-preparation significantly reduced CAP values in patients with T2DM combined with MAFLD compared with TCM-preparation (MD = −15.19, CI [−22.53, −7.85], P < 0.0001).ConclusionTCM-preparation can reduce the CAP value of T2DM combined with MAFLD and can have a good therapeutic effect on glucose-lipid metabolism level and liver function, indicating that TCM-preparation can reduce the deposition of hepatic fat, restore the function of hepatocytes, and have a positive effect on T2DM combined with MAFLD; however, due to the heterogeneity of the included literature, it needs to be further validation by high-quality trials.https://www.frontiersin.org/articles/10.3389/fphar.2025.1578371/fullTCM-preparationmetabolic dysfunction-associated fatty liver disease (MAFLD)type 2 diabetes mellitus (T2DM)meta-analysissystematic review |
| spellingShingle | Jingsi Cao Tingting Bao Jingxian Cao Xuechun Fan Yanyan Wang Jing Yu Ying Wang RuiXue Deng Jingjing Shi Changlong Shen Qingwei Li Jia Mi Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy? Frontiers in Pharmacology TCM-preparation metabolic dysfunction-associated fatty liver disease (MAFLD) type 2 diabetes mellitus (T2DM) meta-analysis systematic review |
| title | Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy? |
| title_full | Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy? |
| title_fullStr | Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy? |
| title_full_unstemmed | Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy? |
| title_short | Metabolic dysfunction-associated fatty liver in type 2 diabetes mellitus patient: can a systematic review of and meta-analysis of commonly used TCM-preparation shed light on their efficacy? |
| title_sort | metabolic dysfunction associated fatty liver in type 2 diabetes mellitus patient can a systematic review of and meta analysis of commonly used tcm preparation shed light on their efficacy |
| topic | TCM-preparation metabolic dysfunction-associated fatty liver disease (MAFLD) type 2 diabetes mellitus (T2DM) meta-analysis systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1578371/full |
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