mRNA vaccines encoding membrane-anchored RBDs of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting

mRNA vaccines encoding membrane-anchored RBDs of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting

We investigated mRNA vaccines encoding a membrane-anchored receptor-binding domain (RBD), each a fusion of a variant RBD, the transmembrane (TM) and cytoplasmic tail fragments of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. In naive mice, RBD-TM mRNA vaccines again...

Full description

Saved in:
Bibliographic Details
Main Authors: Hareth A. Al-Wassiti, Stewart A. Fabb, Samantha L. Grimley, Ruby Kochappan, Joan K. Ho, Chinn Yi Wong, Chee Wah Tan, Thomas J. Payne, Asuka Takanashi, Chee Leng Lee, Rekha Shandre Mugan, Horatio Sicilia, Serena L.Y. Teo, Julie McAuley, Paula Ellenberg, James P. Cooney, Kathryn C. Davidson, Richard Bowen, Marc Pellegrini, Steven Rockman, Dale I. Godfrey, Terry M. Nolan, Lin-fa Wang, Georgia Deliyannis, Damian F.J. Purcell, Colin W. Pouton
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
mRNA vaccine
COVID vaccine
immune imprinting
anchored RBD vaccine
virus neutralization
lipid nanoparticle
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124001967
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items