Measurement of Apelin as a Biomarker and Its Relationship to Cystatin C, Copeptin, and Glomerular Filtration Rate in Serum of Patients with Acute Kidney Injury in Mosul City, Iraq
Background: There is a need for early and accurate diagnosis of acute kidney injury, as high levels of cystatin C, copeptin, and low apelin levels in serum can provide an early diagnosis of acute kidney injury in patients. Objectives: To measure the level of apelin as a biomarker in the blood serum...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-10-01
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| Series: | Medical Journal of Babylon |
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| Online Access: | https://doi.org/10.4103/MJBL.MJBL_1257_23 |
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| author | Anwar S. Majeed Layla A. Mustafa |
| author_facet | Anwar S. Majeed Layla A. Mustafa |
| author_sort | Anwar S. Majeed |
| collection | DOAJ |
| description | Background: There is a need for early and accurate diagnosis of acute kidney injury, as high levels of cystatin C, copeptin, and low apelin levels in serum can provide an early diagnosis of acute kidney injury in patients. Objectives: To measure the level of apelin as a biomarker in the blood serum of both control and acute kidney injury groups, and to find its relationship with each of cystatin C, copeptin, and estimated glomerular filtration rate of both groups. Materials and Methods: This study was conducted on 232 blood samples collected from males and females, 108 from control subjects and 124 from patients with acute kidney injury, aged between 35 and 56 years. Results: Serum apelin (pg/mL) levels decreased in the blood serum of the acute kidney injury patients group, increased both cystatin C and copeptin, and decreased estimated glomerular filtration rate compared to the control group. Conclusion: The results showed that serum apelin levels decreased in the blood serum of the acute kidney injury group, corresponding to an increase in the level of both cystatin C and copeptin levels and a decrease in the estimated glomerular filtration rate compared to the control group, which indicates the possibility that apelin is a strong predictive biomarker for acute kidney injury, and it can play a good preventive and therapeutic role in the future. |
| format | Article |
| id | doaj-art-7b5149a96d2649b782b5b2318c997587 |
| institution | Kabale University |
| issn | 1812-156X 2312-6760 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Babylon |
| spelling | doaj-art-7b5149a96d2649b782b5b2318c9975872025-01-14T11:24:47ZengWolters Kluwer Medknow PublicationsMedical Journal of Babylon1812-156X2312-67602024-10-0121Suppl 2S308S31210.4103/MJBL.MJBL_1257_23Measurement of Apelin as a Biomarker and Its Relationship to Cystatin C, Copeptin, and Glomerular Filtration Rate in Serum of Patients with Acute Kidney Injury in Mosul City, IraqAnwar S. MajeedLayla A. MustafaBackground: There is a need for early and accurate diagnosis of acute kidney injury, as high levels of cystatin C, copeptin, and low apelin levels in serum can provide an early diagnosis of acute kidney injury in patients. Objectives: To measure the level of apelin as a biomarker in the blood serum of both control and acute kidney injury groups, and to find its relationship with each of cystatin C, copeptin, and estimated glomerular filtration rate of both groups. Materials and Methods: This study was conducted on 232 blood samples collected from males and females, 108 from control subjects and 124 from patients with acute kidney injury, aged between 35 and 56 years. Results: Serum apelin (pg/mL) levels decreased in the blood serum of the acute kidney injury patients group, increased both cystatin C and copeptin, and decreased estimated glomerular filtration rate compared to the control group. Conclusion: The results showed that serum apelin levels decreased in the blood serum of the acute kidney injury group, corresponding to an increase in the level of both cystatin C and copeptin levels and a decrease in the estimated glomerular filtration rate compared to the control group, which indicates the possibility that apelin is a strong predictive biomarker for acute kidney injury, and it can play a good preventive and therapeutic role in the future.https://doi.org/10.4103/MJBL.MJBL_1257_23acute kidney injuryegfrserum apelinserum copeptinserum cystatin c |
| spellingShingle | Anwar S. Majeed Layla A. Mustafa Measurement of Apelin as a Biomarker and Its Relationship to Cystatin C, Copeptin, and Glomerular Filtration Rate in Serum of Patients with Acute Kidney Injury in Mosul City, Iraq Medical Journal of Babylon acute kidney injury egfr serum apelin serum copeptin serum cystatin c |
| title | Measurement of Apelin as a Biomarker and Its Relationship to Cystatin C, Copeptin, and Glomerular Filtration Rate in Serum of Patients with Acute Kidney Injury in Mosul City, Iraq |
| title_full | Measurement of Apelin as a Biomarker and Its Relationship to Cystatin C, Copeptin, and Glomerular Filtration Rate in Serum of Patients with Acute Kidney Injury in Mosul City, Iraq |
| title_fullStr | Measurement of Apelin as a Biomarker and Its Relationship to Cystatin C, Copeptin, and Glomerular Filtration Rate in Serum of Patients with Acute Kidney Injury in Mosul City, Iraq |
| title_full_unstemmed | Measurement of Apelin as a Biomarker and Its Relationship to Cystatin C, Copeptin, and Glomerular Filtration Rate in Serum of Patients with Acute Kidney Injury in Mosul City, Iraq |
| title_short | Measurement of Apelin as a Biomarker and Its Relationship to Cystatin C, Copeptin, and Glomerular Filtration Rate in Serum of Patients with Acute Kidney Injury in Mosul City, Iraq |
| title_sort | measurement of apelin as a biomarker and its relationship to cystatin c copeptin and glomerular filtration rate in serum of patients with acute kidney injury in mosul city iraq |
| topic | acute kidney injury egfr serum apelin serum copeptin serum cystatin c |
| url | https://doi.org/10.4103/MJBL.MJBL_1257_23 |
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