Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat
Traumatic spinal cord injury (SCI) is a serious medical condition that places patients at high risk of developing gastric ulceration and gastrointestinal bleeding. One preventative strategy involves the use of omeprazole; however, its chronic use is associated with adverse effects, highlighting the...
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2024-12-01
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| author | Leticia Cruz-Antonio María Elena Sánchez-Mendoza Jazmín García-Machorro Yaraset López-Lorenzo Jesús Arrieta |
| author_facet | Leticia Cruz-Antonio María Elena Sánchez-Mendoza Jazmín García-Machorro Yaraset López-Lorenzo Jesús Arrieta |
| author_sort | Leticia Cruz-Antonio |
| collection | DOAJ |
| description | Traumatic spinal cord injury (SCI) is a serious medical condition that places patients at high risk of developing gastric ulceration and gastrointestinal bleeding. One preventative strategy involves the use of omeprazole; however, its chronic use is associated with adverse effects, highlighting the need for alternative therapies. This study evaluated the protective effects of methyl eugenol (ME) on gastric mucosal damage in a rat model of SCI. ME was administered orally at doses of 30, 100, and 177 mg/kg in SCI induced at the T9 level, alongside diclofenac or ketorolac (30 mg/kg each). The enzymatic activity of superoxide dismutase, catalase, and glutathione peroxidase was assessed, and the levels of total glutathione and malondialdehyde were determined using biochemical kits. Additionally, stomach histological sections were analyzed. ME exhibited dose-dependent gastroprotective effects, with maximal protection observed at 177 mg/kg in the presence of diclofenac (9.78 ± 2.16 mm<sup>2</sup>) or ketorolac (12.49 ± 2.17 mm<sup>2</sup>). A histological analysis confirmed these findings. In conclusion, methyl eugenol protects the gastric mucosa from SCI-induced damage, with glutathione peroxidase and catalase playing key roles in its mechanism of gastroprotection. |
| format | Article |
| id | doaj-art-7b4d6309d1b04644a76f5fb686263ffb |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Molecules |
| spelling | doaj-art-7b4d6309d1b04644a76f5fb686263ffb2025-01-10T13:18:50ZengMDPI AGMolecules1420-30492024-12-013018610.3390/molecules30010086Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the RatLeticia Cruz-Antonio0María Elena Sánchez-Mendoza1Jazmín García-Machorro2Yaraset López-Lorenzo3Jesús Arrieta4Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México (UNAM), Av. Guelatao No. 66, Colonia Ejército de Oriente, Iztapalapa, Ciudad de México 09230, MexicoLaboratorio de Farmacología de Plantas Medicinales Mexicanas, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, Miguel Hidalgo, Ciudad de México 11340, MexicoLaboratorio de Medicina de la Conservación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, Miguel Hidalgo, Ciudad de México 11340, MexicoLaboratorio de Farmacología de Plantas Medicinales Mexicanas, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, Miguel Hidalgo, Ciudad de México 11340, MexicoLaboratorio de Farmacología de Plantas Medicinales Mexicanas, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo Tomás, Miguel Hidalgo, Ciudad de México 11340, MexicoTraumatic spinal cord injury (SCI) is a serious medical condition that places patients at high risk of developing gastric ulceration and gastrointestinal bleeding. One preventative strategy involves the use of omeprazole; however, its chronic use is associated with adverse effects, highlighting the need for alternative therapies. This study evaluated the protective effects of methyl eugenol (ME) on gastric mucosal damage in a rat model of SCI. ME was administered orally at doses of 30, 100, and 177 mg/kg in SCI induced at the T9 level, alongside diclofenac or ketorolac (30 mg/kg each). The enzymatic activity of superoxide dismutase, catalase, and glutathione peroxidase was assessed, and the levels of total glutathione and malondialdehyde were determined using biochemical kits. Additionally, stomach histological sections were analyzed. ME exhibited dose-dependent gastroprotective effects, with maximal protection observed at 177 mg/kg in the presence of diclofenac (9.78 ± 2.16 mm<sup>2</sup>) or ketorolac (12.49 ± 2.17 mm<sup>2</sup>). A histological analysis confirmed these findings. In conclusion, methyl eugenol protects the gastric mucosa from SCI-induced damage, with glutathione peroxidase and catalase playing key roles in its mechanism of gastroprotection.https://www.mdpi.com/1420-3049/30/1/86gastroprotectionspinal cord injurymethyl eugenol |
| spellingShingle | Leticia Cruz-Antonio María Elena Sánchez-Mendoza Jazmín García-Machorro Yaraset López-Lorenzo Jesús Arrieta Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat Molecules gastroprotection spinal cord injury methyl eugenol |
| title | Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat |
| title_full | Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat |
| title_fullStr | Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat |
| title_full_unstemmed | Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat |
| title_short | Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat |
| title_sort | study of the effect of methyl eugenol on gastric damage produced by spinal cord injury model in the rat |
| topic | gastroprotection spinal cord injury methyl eugenol |
| url | https://www.mdpi.com/1420-3049/30/1/86 |
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