Metabolite profiling of some organs and the potential of Mukia javanica as an antihypertension
Mukia javanica is a close relative of the cucumber (Cucumis sativus) used to treat hypertension in the Leuwiliang community. Cucumis sativus contains calcium, magnesium, potassium, and phosphorus, which help lower blood pressure. In contrast, the content of metabolite compounds that are useful for l...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Sustainable Food Systems |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsufs.2024.1487446/full |
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| author | Mentari Putri Pratami Mentari Putri Pratami Wawan Sujarwo Miftahul Huda Fendiyanto Ratna Yuniati Ifan Rizky Kurniyanto Nuniek Widiayani Mahmoud F. Seleiman Nawab Ali Muhammad Fuad Anshori |
| author_facet | Mentari Putri Pratami Mentari Putri Pratami Wawan Sujarwo Miftahul Huda Fendiyanto Ratna Yuniati Ifan Rizky Kurniyanto Nuniek Widiayani Mahmoud F. Seleiman Nawab Ali Muhammad Fuad Anshori |
| author_sort | Mentari Putri Pratami |
| collection | DOAJ |
| description | Mukia javanica is a close relative of the cucumber (Cucumis sativus) used to treat hypertension in the Leuwiliang community. Cucumis sativus contains calcium, magnesium, potassium, and phosphorus, which help lower blood pressure. In contrast, the content of metabolite compounds that are useful for lowering blood pressure in M. javanica has not been previously reported. Therefore, this research aimed to identify and determine the secondary metabolite content contained in several M. javanica organs and determine potential compounds that function in treating hypertension. The method used is the gas chromatography–mass spectrometry (GCMS) method. The samples analyzed included several organs of M. javanica, such as roots, stems, leaves, and fruit. Several organs are tested to determine the part of the plant with the most potential secondary metabolite compound content. Data analysis used the R version 3.5.2 program and the Metaboanalyst program. Based on the test results, 98 secondary metabolite compounds were identified and divided into several compound classes, and the most significant number of compounds identified was the terpenoid compound group. The 13-Tetradecen-1-acetate (root), Oleic acid (fruit), Phytol (stem), and 4-hydroxy-3-nitrocoumarin (root) content in Mukia javanica has the potential to be antihypertensive. Based on correlation analysis, the metabolites Hexadecanoic Acid Methyl Ester, Squalene, Vitamin E, and Stigmasta-7,16-Dien-3 show high correlation values. The compound Hexadecanoic Acid Methyl Ester is found in all parts, and it is reported to be associated with antihypertension and antioxidants. In the future, this compound has the potential to be used as a raw material for antihypertensive drugs. |
| format | Article |
| id | doaj-art-7b33243fe88e4a059a7ed2e30c01447d |
| institution | Kabale University |
| issn | 2571-581X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Sustainable Food Systems |
| spelling | doaj-art-7b33243fe88e4a059a7ed2e30c01447d2025-01-03T04:10:53ZengFrontiers Media S.A.Frontiers in Sustainable Food Systems2571-581X2025-01-01810.3389/fsufs.2024.14874461487446Metabolite profiling of some organs and the potential of Mukia javanica as an antihypertensionMentari Putri Pratami0Mentari Putri Pratami1Wawan Sujarwo2Miftahul Huda Fendiyanto3Ratna Yuniati4Ifan Rizky Kurniyanto5Nuniek Widiayani6Mahmoud F. Seleiman7Nawab Ali8Muhammad Fuad Anshori9National Research and Innovation Agency of Indonesia (BRIN), Bogor, IndonesiaDepartment of Biology, Faculty of Military Mathematics and Natural Sciences, Kawasan IPSC, The Republic of Indonesia Defense University, Kampus Universitas Pertahanan Sentul, Bogor, West Java, IndonesiaNational Research and Innovation Agency of Indonesia (BRIN), Bogor, IndonesiaDepartment of Biology, Faculty of Military Mathematics and Natural Sciences, Kawasan IPSC, The Republic of Indonesia Defense University, Kampus Universitas Pertahanan Sentul, Bogor, West Java, IndonesiaDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, IndonesiaDepartment of Agricultural Science and Technology, Faculty of Agriculture, Universitas Trunojoyo Madura, Bangkalan, IndonesiaDepartment of Agronomy, Faculty of Agriculture, Hasanuddin University, Makassar, IndonesiaPlant Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi ArabiaDepartment of Biosystems and Agricultural Engineering (BAE), College of Agriculture and Natural 19 Resources, Michigan State University, East Lansing, MI, United StatesDepartment of Agronomy, Faculty of Agriculture, Hasanuddin University, Makassar, IndonesiaMukia javanica is a close relative of the cucumber (Cucumis sativus) used to treat hypertension in the Leuwiliang community. Cucumis sativus contains calcium, magnesium, potassium, and phosphorus, which help lower blood pressure. In contrast, the content of metabolite compounds that are useful for lowering blood pressure in M. javanica has not been previously reported. Therefore, this research aimed to identify and determine the secondary metabolite content contained in several M. javanica organs and determine potential compounds that function in treating hypertension. The method used is the gas chromatography–mass spectrometry (GCMS) method. The samples analyzed included several organs of M. javanica, such as roots, stems, leaves, and fruit. Several organs are tested to determine the part of the plant with the most potential secondary metabolite compound content. Data analysis used the R version 3.5.2 program and the Metaboanalyst program. Based on the test results, 98 secondary metabolite compounds were identified and divided into several compound classes, and the most significant number of compounds identified was the terpenoid compound group. The 13-Tetradecen-1-acetate (root), Oleic acid (fruit), Phytol (stem), and 4-hydroxy-3-nitrocoumarin (root) content in Mukia javanica has the potential to be antihypertensive. Based on correlation analysis, the metabolites Hexadecanoic Acid Methyl Ester, Squalene, Vitamin E, and Stigmasta-7,16-Dien-3 show high correlation values. The compound Hexadecanoic Acid Methyl Ester is found in all parts, and it is reported to be associated with antihypertension and antioxidants. In the future, this compound has the potential to be used as a raw material for antihypertensive drugs.https://www.frontiersin.org/articles/10.3389/fsufs.2024.1487446/fullantihypertensiveantioxidantcorrelation analysisGCMSMukia javanica |
| spellingShingle | Mentari Putri Pratami Mentari Putri Pratami Wawan Sujarwo Miftahul Huda Fendiyanto Ratna Yuniati Ifan Rizky Kurniyanto Nuniek Widiayani Mahmoud F. Seleiman Nawab Ali Muhammad Fuad Anshori Metabolite profiling of some organs and the potential of Mukia javanica as an antihypertension Frontiers in Sustainable Food Systems antihypertensive antioxidant correlation analysis GCMS Mukia javanica |
| title | Metabolite profiling of some organs and the potential of Mukia javanica as an antihypertension |
| title_full | Metabolite profiling of some organs and the potential of Mukia javanica as an antihypertension |
| title_fullStr | Metabolite profiling of some organs and the potential of Mukia javanica as an antihypertension |
| title_full_unstemmed | Metabolite profiling of some organs and the potential of Mukia javanica as an antihypertension |
| title_short | Metabolite profiling of some organs and the potential of Mukia javanica as an antihypertension |
| title_sort | metabolite profiling of some organs and the potential of mukia javanica as an antihypertension |
| topic | antihypertensive antioxidant correlation analysis GCMS Mukia javanica |
| url | https://www.frontiersin.org/articles/10.3389/fsufs.2024.1487446/full |
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