The impact of close surgical margins on recurrence in oral squamous cell carcinoma
Abstract Background Close margins influence treatment and outcome in patients with oral squamous cell carcinoma (OSCC). This study evaluates 187 cases of surgically treated OSCC regarding the impact of close margins on recurrence-free survival (RFS) and disease-specific survival (DSS). Methods Predi...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-02-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1186/s40463-020-00483-w |
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| _version_ | 1841561343259312128 |
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| author | Joseph Solomon Ashley Hinther T. Wayne Matthews Steven C. Nakoneshny Rob Hart Joseph C. Dort Shamir P. Chandarana |
| author_facet | Joseph Solomon Ashley Hinther T. Wayne Matthews Steven C. Nakoneshny Rob Hart Joseph C. Dort Shamir P. Chandarana |
| author_sort | Joseph Solomon |
| collection | DOAJ |
| description | Abstract Background Close margins influence treatment and outcome in patients with oral squamous cell carcinoma (OSCC). This study evaluates 187 cases of surgically treated OSCC regarding the impact of close margins on recurrence-free survival (RFS) and disease-specific survival (DSS). Methods Predictors of worsened outcome were identified using Kaplan-Meier analysis and multivariate Cox regression analysis. Results Tumour size [HR:1.70(0.95–3.08)], nodal status [HR:2.15(1.00–4.64)], presence of extracapsular spread (ECS) [HR:6.36(2.41–16.74)] and smoking history [HR:2.87(1.19–6.86)] were associated with worsened RFS. Similar factors were associated with worsened DSS. Close margins did not influence RFS or DSS. Conclusions While most conventional risk factors for OSCC conferred a worsened outcome, close margins did not. One explanation for this would be that close margins (< 5 mm) are equivalent to clear margins and the cutoff definition for a close margin should be re-evaluated. Lack of standardized pathology could also reduce accuracy of reporting of close surgical margins. Graphical abstract |
| format | Article |
| id | doaj-art-7b275ea2dfb54887b505de93f8ea59d9 |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-7b275ea2dfb54887b505de93f8ea59d92025-01-03T01:45:48ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162021-02-015011710.1186/s40463-020-00483-wThe impact of close surgical margins on recurrence in oral squamous cell carcinomaJoseph Solomon0Ashley Hinther1T. Wayne Matthews2Steven C. Nakoneshny3Rob Hart4Joseph C. Dort5Shamir P. Chandarana6Cumming School of Medicine, University of CalgaryCumming School of Medicine, University of CalgaryDepartment of Surgery, Section of Otolaryngology – Head & Neck SurgeryOhlson Research Initiative, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of CalgaryDepartment of Surgery, Section of Otolaryngology – Head & Neck SurgeryDepartment of Surgery, Section of Otolaryngology – Head & Neck SurgeryDepartment of Surgery, Section of Otolaryngology – Head & Neck SurgeryAbstract Background Close margins influence treatment and outcome in patients with oral squamous cell carcinoma (OSCC). This study evaluates 187 cases of surgically treated OSCC regarding the impact of close margins on recurrence-free survival (RFS) and disease-specific survival (DSS). Methods Predictors of worsened outcome were identified using Kaplan-Meier analysis and multivariate Cox regression analysis. Results Tumour size [HR:1.70(0.95–3.08)], nodal status [HR:2.15(1.00–4.64)], presence of extracapsular spread (ECS) [HR:6.36(2.41–16.74)] and smoking history [HR:2.87(1.19–6.86)] were associated with worsened RFS. Similar factors were associated with worsened DSS. Close margins did not influence RFS or DSS. Conclusions While most conventional risk factors for OSCC conferred a worsened outcome, close margins did not. One explanation for this would be that close margins (< 5 mm) are equivalent to clear margins and the cutoff definition for a close margin should be re-evaluated. Lack of standardized pathology could also reduce accuracy of reporting of close surgical margins. Graphical abstracthttps://doi.org/10.1186/s40463-020-00483-wMarginOral cavitySquamous cell carcinomaRecurrencePathology |
| spellingShingle | Joseph Solomon Ashley Hinther T. Wayne Matthews Steven C. Nakoneshny Rob Hart Joseph C. Dort Shamir P. Chandarana The impact of close surgical margins on recurrence in oral squamous cell carcinoma Journal of Otolaryngology - Head and Neck Surgery Margin Oral cavity Squamous cell carcinoma Recurrence Pathology |
| title | The impact of close surgical margins on recurrence in oral squamous cell carcinoma |
| title_full | The impact of close surgical margins on recurrence in oral squamous cell carcinoma |
| title_fullStr | The impact of close surgical margins on recurrence in oral squamous cell carcinoma |
| title_full_unstemmed | The impact of close surgical margins on recurrence in oral squamous cell carcinoma |
| title_short | The impact of close surgical margins on recurrence in oral squamous cell carcinoma |
| title_sort | impact of close surgical margins on recurrence in oral squamous cell carcinoma |
| topic | Margin Oral cavity Squamous cell carcinoma Recurrence Pathology |
| url | https://doi.org/10.1186/s40463-020-00483-w |
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