Mutual mediation effects of homocysteine and PCSK9 on coronary lesion severity in patients with acute coronary syndrome: interplay with inflammatory and lipid markers

Mutual mediation effects of homocysteine and PCSK9 on coronary lesion severity in patients with acute coronary syndrome: interplay with inflammatory and lipid markers

Abstract Background Homocysteine (Hcy) and the proprotein convertase subtilisin/kexin type 9 (PCSK9) significantly contribute to atherosclerosis (AS) as well as coronary lesion severity. Our previous work demonstrated that Hcy upregulates PCSK9, accelerating lipid accumulation and AS. A PCSK9 antago...

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Bibliographic Details
Main Authors: Ping Jin, Juan Ma, Peng Wu, Yitong Bian, Xueping Ma, Shaobin Jia, Qiangsun Zheng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Lipids in Health and Disease
Subjects:
Homocysteine
PCSK9
Acute coronary syndrome
Mediation analysis
Inflammation
Lipid metabolism
Online Access:https://doi.org/10.1186/s12944-025-02443-7
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