Comprehensive Insights into Mechanisms for Ventricular Remodeling in Right Heart Failure
Ventricular remodeling in right heart failure is a complex pathological process involving interactions between multiple mechanisms. Overactivation of the neuro-hormonal pathways, activation of the oxidative stress response, expression of cytokines, apoptosis of cardiomyocytes, and alterations of the...
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| Format: | Article |
| Language: | English |
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IMR Press
2024-11-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/25/12/10.31083/j.rcm2512426 |
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| _version_ | 1846100332050907136 |
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| author | Dongmei Jiang Jie Wang Rui Wang Yun Wu |
| author_facet | Dongmei Jiang Jie Wang Rui Wang Yun Wu |
| author_sort | Dongmei Jiang |
| collection | DOAJ |
| description | Ventricular remodeling in right heart failure is a complex pathological process involving interactions between multiple mechanisms. Overactivation of the neuro-hormonal pathways, activation of the oxidative stress response, expression of cytokines, apoptosis of cardiomyocytes, and alterations of the extracellular matrix (ECM) are among the major mechanisms involved in the development of ventricular remodeling in right heart failure. These mechanisms are involved in ventricular remodeling, such as myocardial hypertrophy and fibrosis, leading to the deterioration of myocardial systolic and diastolic function. A deeper understanding of these mechanisms can help develop more effective therapeutic strategies in patients with right heart failure (RHF) to improve patient survival and quality of life. Despite the importance of ventricular remodeling in RHF, there are a limited number of studies in this field. This article explores in-depth historical and current information about the specific mechanisms in ventricular remodeling in RHF, providing a theoretical rationale for recognizing its importance in health and disease. |
| format | Article |
| id | doaj-art-7afebc1efefb4e8d851032a761cf9cb7 |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-7afebc1efefb4e8d851032a761cf9cb72024-12-30T09:51:26ZengIMR PressReviews in Cardiovascular Medicine1530-65502024-11-01251242610.31083/j.rcm2512426S1530-6550(24)01536-9Comprehensive Insights into Mechanisms for Ventricular Remodeling in Right Heart FailureDongmei Jiang0Jie Wang1Rui Wang2Yun Wu3Department of General Medicine, First Affiliated Hospital of Xinjiang Medical University, 830011 Urumchi, Xinjiang, ChinaDepartment of Pharmacy, First Affiliated Hospital of Xinjiang Medical University, 830011 Urumchi, Xinjiang, ChinaDepartment of General Medicine, First Affiliated Hospital of Xinjiang Medical University, 830011 Urumchi, Xinjiang, ChinaDepartment of General Medicine, First Affiliated Hospital of Xinjiang Medical University, 830011 Urumchi, Xinjiang, ChinaVentricular remodeling in right heart failure is a complex pathological process involving interactions between multiple mechanisms. Overactivation of the neuro-hormonal pathways, activation of the oxidative stress response, expression of cytokines, apoptosis of cardiomyocytes, and alterations of the extracellular matrix (ECM) are among the major mechanisms involved in the development of ventricular remodeling in right heart failure. These mechanisms are involved in ventricular remodeling, such as myocardial hypertrophy and fibrosis, leading to the deterioration of myocardial systolic and diastolic function. A deeper understanding of these mechanisms can help develop more effective therapeutic strategies in patients with right heart failure (RHF) to improve patient survival and quality of life. Despite the importance of ventricular remodeling in RHF, there are a limited number of studies in this field. This article explores in-depth historical and current information about the specific mechanisms in ventricular remodeling in RHF, providing a theoretical rationale for recognizing its importance in health and disease.https://www.imrpress.com/journal/RCM/25/12/10.31083/j.rcm2512426right heart failureventricular remodelingautonomic nervous systemcytokinesextracellular matrix |
| spellingShingle | Dongmei Jiang Jie Wang Rui Wang Yun Wu Comprehensive Insights into Mechanisms for Ventricular Remodeling in Right Heart Failure Reviews in Cardiovascular Medicine right heart failure ventricular remodeling autonomic nervous system cytokines extracellular matrix |
| title | Comprehensive Insights into Mechanisms for Ventricular Remodeling in Right Heart Failure |
| title_full | Comprehensive Insights into Mechanisms for Ventricular Remodeling in Right Heart Failure |
| title_fullStr | Comprehensive Insights into Mechanisms for Ventricular Remodeling in Right Heart Failure |
| title_full_unstemmed | Comprehensive Insights into Mechanisms for Ventricular Remodeling in Right Heart Failure |
| title_short | Comprehensive Insights into Mechanisms for Ventricular Remodeling in Right Heart Failure |
| title_sort | comprehensive insights into mechanisms for ventricular remodeling in right heart failure |
| topic | right heart failure ventricular remodeling autonomic nervous system cytokines extracellular matrix |
| url | https://www.imrpress.com/journal/RCM/25/12/10.31083/j.rcm2512426 |
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