Development of a near infrared region based non-invasive therapy device for diabetic peripheral neuropathy
Abstract Diabetic Peripheral Neuropathy (DPN) is a nerve damage that is treated with painkillers and steroids which have the drawback of interference with other medications and the dangers of side effects. Novelty of the proposed work is to develop a Near Infrared Region (NIR) based non-invasive the...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-78144-5 |
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| author | S. V. K. R. Rajeswari Vijayakumar Ponnusamy Nemanja Zdravkovic Emilija Kisic V. Padmajothi S. Vijayalakshmi C. Anuradha D. Malathi Nandakumar Ramasamy Kumar Janardhan Melvin George |
| author_facet | S. V. K. R. Rajeswari Vijayakumar Ponnusamy Nemanja Zdravkovic Emilija Kisic V. Padmajothi S. Vijayalakshmi C. Anuradha D. Malathi Nandakumar Ramasamy Kumar Janardhan Melvin George |
| author_sort | S. V. K. R. Rajeswari |
| collection | DOAJ |
| description | Abstract Diabetic Peripheral Neuropathy (DPN) is a nerve damage that is treated with painkillers and steroids which have the drawback of interference with other medications and the dangers of side effects. Novelty of the proposed work is to develop a Near Infrared Region (NIR) based non-invasive therapy device called ‘DPNrelief-1.0V’developed with a 890 nm wavelength diodes. DPNrelief-1.0V delivers a total dosage of 6.174 J/cm2 with heat absorption by tissue of 61.74 Joules at 30 minutes. The device was tested by carrying out a pilot study with 8 patients where 4 were treatment group and control group. The DPNrelief-1.0V is validated by Nerve Conduction Study (NCS) test. The degenerated nerves pre-therapy showed less amplitude, Conduction Velocity (CV) and latency which was improved post-therapy by 100% in amplitude of nerve signal, 100% in CV and a decrease of 36.2% in latency. Independent t-test was conducted to find the difference between control and treatment, wherein a p value < 0.05 was obtained depicting significant difference between two groups. Furthermore, the performance of the device is validated by one-way test repeated measures Analysis of Variance (ANOVA), wherein a p value of < 0.05 was obtained depicting a difference in nerve condition pre-and post-therapy. The performance of DPNrelief-1.0V has outperformed Anodyne therapy device with lesser dosage, treatment time and portability and in curing the symptoms of DPN. DPNrelief-1.0V finds its potential in the field of medicine for treating DPN. |
| format | Article |
| id | doaj-art-7afb73e774e443d6b7889d92c207f67f |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-7afb73e774e443d6b7889d92c207f67f2024-11-17T12:20:29ZengNature PortfolioScientific Reports2045-23222024-11-0114111210.1038/s41598-024-78144-5Development of a near infrared region based non-invasive therapy device for diabetic peripheral neuropathyS. V. K. R. Rajeswari0Vijayakumar Ponnusamy1Nemanja Zdravkovic2Emilija Kisic3V. Padmajothi4S. Vijayalakshmi5C. Anuradha6D. Malathi7Nandakumar Ramasamy8Kumar Janardhan9Melvin George10Department of Electronics and Communication Engineering, SRM Institute of Science and TechnologyDepartment of Electronics and Communication Engineering, SRM Institute of Science and TechnologyFaculty of Information Technology, Belgrade Metropolitan UniversityFaculty of Information Technology, Belgrade Metropolitan UniversityDepartment of Electronics and Communication Engineering, SRM Institute of Science and TechnologyDepartment of Electrical and Electronics Engineering, SRM Institute of Science and TechnologyDepartment of Electrical and Electronics Engineering, SRM Institute of Science and TechnologyDepartment of Electronics and Communication Engineering, Kongu Engineering College Department of ECE, K.S.R. College of EngineeringDepartment of General Medicine, SRM Medical College Hospital and Research CenterDepartment of Clinical Pharmacology, SRM Medical College Hospital and Research CenterAbstract Diabetic Peripheral Neuropathy (DPN) is a nerve damage that is treated with painkillers and steroids which have the drawback of interference with other medications and the dangers of side effects. Novelty of the proposed work is to develop a Near Infrared Region (NIR) based non-invasive therapy device called ‘DPNrelief-1.0V’developed with a 890 nm wavelength diodes. DPNrelief-1.0V delivers a total dosage of 6.174 J/cm2 with heat absorption by tissue of 61.74 Joules at 30 minutes. The device was tested by carrying out a pilot study with 8 patients where 4 were treatment group and control group. The DPNrelief-1.0V is validated by Nerve Conduction Study (NCS) test. The degenerated nerves pre-therapy showed less amplitude, Conduction Velocity (CV) and latency which was improved post-therapy by 100% in amplitude of nerve signal, 100% in CV and a decrease of 36.2% in latency. Independent t-test was conducted to find the difference between control and treatment, wherein a p value < 0.05 was obtained depicting significant difference between two groups. Furthermore, the performance of the device is validated by one-way test repeated measures Analysis of Variance (ANOVA), wherein a p value of < 0.05 was obtained depicting a difference in nerve condition pre-and post-therapy. The performance of DPNrelief-1.0V has outperformed Anodyne therapy device with lesser dosage, treatment time and portability and in curing the symptoms of DPN. DPNrelief-1.0V finds its potential in the field of medicine for treating DPN.https://doi.org/10.1038/s41598-024-78144-5Diabetic peripheral neuropathyNear infrared spectroscopy therapyNerve conduction studyHardware designTherapy device |
| spellingShingle | S. V. K. R. Rajeswari Vijayakumar Ponnusamy Nemanja Zdravkovic Emilija Kisic V. Padmajothi S. Vijayalakshmi C. Anuradha D. Malathi Nandakumar Ramasamy Kumar Janardhan Melvin George Development of a near infrared region based non-invasive therapy device for diabetic peripheral neuropathy Scientific Reports Diabetic peripheral neuropathy Near infrared spectroscopy therapy Nerve conduction study Hardware design Therapy device |
| title | Development of a near infrared region based non-invasive therapy device for diabetic peripheral neuropathy |
| title_full | Development of a near infrared region based non-invasive therapy device for diabetic peripheral neuropathy |
| title_fullStr | Development of a near infrared region based non-invasive therapy device for diabetic peripheral neuropathy |
| title_full_unstemmed | Development of a near infrared region based non-invasive therapy device for diabetic peripheral neuropathy |
| title_short | Development of a near infrared region based non-invasive therapy device for diabetic peripheral neuropathy |
| title_sort | development of a near infrared region based non invasive therapy device for diabetic peripheral neuropathy |
| topic | Diabetic peripheral neuropathy Near infrared spectroscopy therapy Nerve conduction study Hardware design Therapy device |
| url | https://doi.org/10.1038/s41598-024-78144-5 |
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