PREDICTORS OF MORTALITY IN MECHANICALLY VENTILATED CRITICAL PERTUSSIS IN A LOW INCOME COUNTRY: NEW RESURGENCE IN 2013.
Background: Critical pertussis is characterized by severe respiratory failure, severe leukocytosis, pulmonary hypertension, septic shock and encephalopathy. Aim: To describe the clinical course of critical pertussis and identify predictors of death at the time of presentation for medical care. Met...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-09-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2033 |
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| author | Aida Borgi |
| author_facet | Aida Borgi |
| author_sort | Aida Borgi |
| collection | DOAJ |
| description | Background: Critical pertussis is characterized by severe respiratory failure, severe leukocytosis, pulmonary hypertension, septic shock and encephalopathy.
Aim: To describe the clinical course of critical pertussis and identify predictors of death at the time of presentation for medical care.
Methodology: retrospective study conducted in children’s hospital Tunisian PICU between 01 January and 31 october 2013. Patients with critical pertussis confirmed by RT-PCR and requiring mechanical ventilation were included. Predictors of death were studied.
Results : A total of 17 patients were included. Median age was 50 days. Mortality was 23%. Predictors risk of mortality were high PRISM (p=0,007), shock (p=0,002), tachycardia (p=0,005), seizures (p=0,006), altered mental status(p=0,006), elevated WBC count (p=0,003) and hemodynamic support (p=0022). However difference did not reach statistical significance in comorbidity, pneumoniae, high pulmonary hypertension or exchange transfusion. Concomitant viral or bacterial coinfection wasn’t related to poor outcome.
Conclusion: Young infants are at high risk to have critical pertussis. Despite advances in life support and the treatment of organ failure in childhood critical illness, critical pertussis remains difficult to treat. |
| format | Article |
| id | doaj-art-7af54d853b8e467f99dcce94e3802f8a |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-7af54d853b8e467f99dcce94e3802f8a2025-01-02T01:19:01ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062014-09-0161e2014059e201405910.4084/mjhid.2014.0591489PREDICTORS OF MORTALITY IN MECHANICALLY VENTILATED CRITICAL PERTUSSIS IN A LOW INCOME COUNTRY: NEW RESURGENCE IN 2013.Aida Borgi0PICU- Children’s Hospital of TunisBackground: Critical pertussis is characterized by severe respiratory failure, severe leukocytosis, pulmonary hypertension, septic shock and encephalopathy. Aim: To describe the clinical course of critical pertussis and identify predictors of death at the time of presentation for medical care. Methodology: retrospective study conducted in children’s hospital Tunisian PICU between 01 January and 31 october 2013. Patients with critical pertussis confirmed by RT-PCR and requiring mechanical ventilation were included. Predictors of death were studied. Results : A total of 17 patients were included. Median age was 50 days. Mortality was 23%. Predictors risk of mortality were high PRISM (p=0,007), shock (p=0,002), tachycardia (p=0,005), seizures (p=0,006), altered mental status(p=0,006), elevated WBC count (p=0,003) and hemodynamic support (p=0022). However difference did not reach statistical significance in comorbidity, pneumoniae, high pulmonary hypertension or exchange transfusion. Concomitant viral or bacterial coinfection wasn’t related to poor outcome. Conclusion: Young infants are at high risk to have critical pertussis. Despite advances in life support and the treatment of organ failure in childhood critical illness, critical pertussis remains difficult to treat.http://www.mjhid.org/index.php/mjhid/article/view/2033critical pertussis, ventilation, predictors of mortality |
| spellingShingle | Aida Borgi PREDICTORS OF MORTALITY IN MECHANICALLY VENTILATED CRITICAL PERTUSSIS IN A LOW INCOME COUNTRY: NEW RESURGENCE IN 2013. Mediterranean Journal of Hematology and Infectious Diseases critical pertussis, ventilation, predictors of mortality |
| title | PREDICTORS OF MORTALITY IN MECHANICALLY VENTILATED CRITICAL PERTUSSIS IN A LOW INCOME COUNTRY: NEW RESURGENCE IN 2013. |
| title_full | PREDICTORS OF MORTALITY IN MECHANICALLY VENTILATED CRITICAL PERTUSSIS IN A LOW INCOME COUNTRY: NEW RESURGENCE IN 2013. |
| title_fullStr | PREDICTORS OF MORTALITY IN MECHANICALLY VENTILATED CRITICAL PERTUSSIS IN A LOW INCOME COUNTRY: NEW RESURGENCE IN 2013. |
| title_full_unstemmed | PREDICTORS OF MORTALITY IN MECHANICALLY VENTILATED CRITICAL PERTUSSIS IN A LOW INCOME COUNTRY: NEW RESURGENCE IN 2013. |
| title_short | PREDICTORS OF MORTALITY IN MECHANICALLY VENTILATED CRITICAL PERTUSSIS IN A LOW INCOME COUNTRY: NEW RESURGENCE IN 2013. |
| title_sort | predictors of mortality in mechanically ventilated critical pertussis in a low income country new resurgence in 2013 |
| topic | critical pertussis, ventilation, predictors of mortality |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2033 |
| work_keys_str_mv | AT aidaborgi predictorsofmortalityinmechanicallyventilatedcriticalpertussisinalowincomecountrynewresurgencein2013 |