Effect of selective dorsal rhizotomy on bladder dysfunction in children with spastic cerebral palsy
Abstract This study investigated the prevalence and severity of lower urinary tract symptoms (LUTS) in children with spastic cerebral palsy (SCP) and evaluated the effect of selective dorsal rhizotomy (SDR) in alleviating these symptoms. The study also explored the correlation between postoperative...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-81512-w |
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| author | Wenbin Jiang Junlu Wang Pierre A. Robe Min Wei Sen Li Rui Wang Qijia Zhan Bo Xiao |
| author_facet | Wenbin Jiang Junlu Wang Pierre A. Robe Min Wei Sen Li Rui Wang Qijia Zhan Bo Xiao |
| author_sort | Wenbin Jiang |
| collection | DOAJ |
| description | Abstract This study investigated the prevalence and severity of lower urinary tract symptoms (LUTS) in children with spastic cerebral palsy (SCP) and evaluated the effect of selective dorsal rhizotomy (SDR) in alleviating these symptoms. The study also explored the correlation between postoperative LUTS improvement and intraoperative electrophysiological findings. Prospective data were collected from a consecutive cohort of 247 children with SCP who underwent SDR and were retrospectively analyzed. Pre- and post-operative assessments included muscle tone, motor function, LUTS and intraoperative electrophysiology data were analyzed. Preoperatively, 94 patients (38.1%) had LUTS, and the severity of LUTS negatively correlated with motor function (R=-0.32, P < 0.0001). After SDR, muscle tone decreased, motor function improved (P < 0.0001), and LUTS resolved in 49/94 patients (52.1%). LUTS improvement correlated with a higher proportion of sensory nerves evoking anal sphincter EMG > 20µV. SDR effectively reduces spasticity, improves motor function, and alleviates LUTS in most children with SCP. Intraoperative neurophysiology may predict improvements, warranting further research. |
| format | Article |
| id | doaj-art-7ae7035e51954e95ac9b6d9cae180f9b |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-7ae7035e51954e95ac9b6d9cae180f9b2025-01-05T12:27:31ZengNature PortfolioScientific Reports2045-23222024-12-0114111010.1038/s41598-024-81512-wEffect of selective dorsal rhizotomy on bladder dysfunction in children with spastic cerebral palsyWenbin Jiang0Junlu Wang1Pierre A. Robe2Min Wei3Sen Li4Rui Wang5Qijia Zhan6Bo Xiao7Department of Neurosurgery, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Neurosurgery, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Neurology and Neurosurgery, University Medical Center of UtrechtDepartment of Neurosurgery, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Neurosurgery, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Neurosurgery, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Neurosurgery, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Neurosurgery, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityAbstract This study investigated the prevalence and severity of lower urinary tract symptoms (LUTS) in children with spastic cerebral palsy (SCP) and evaluated the effect of selective dorsal rhizotomy (SDR) in alleviating these symptoms. The study also explored the correlation between postoperative LUTS improvement and intraoperative electrophysiological findings. Prospective data were collected from a consecutive cohort of 247 children with SCP who underwent SDR and were retrospectively analyzed. Pre- and post-operative assessments included muscle tone, motor function, LUTS and intraoperative electrophysiology data were analyzed. Preoperatively, 94 patients (38.1%) had LUTS, and the severity of LUTS negatively correlated with motor function (R=-0.32, P < 0.0001). After SDR, muscle tone decreased, motor function improved (P < 0.0001), and LUTS resolved in 49/94 patients (52.1%). LUTS improvement correlated with a higher proportion of sensory nerves evoking anal sphincter EMG > 20µV. SDR effectively reduces spasticity, improves motor function, and alleviates LUTS in most children with SCP. Intraoperative neurophysiology may predict improvements, warranting further research.https://doi.org/10.1038/s41598-024-81512-wSelective dorsal rhizotomySpastic cerebral palsyLower urinary tract symptomsIntraoperative neurophysiological monitoringBladder dysfunction |
| spellingShingle | Wenbin Jiang Junlu Wang Pierre A. Robe Min Wei Sen Li Rui Wang Qijia Zhan Bo Xiao Effect of selective dorsal rhizotomy on bladder dysfunction in children with spastic cerebral palsy Scientific Reports Selective dorsal rhizotomy Spastic cerebral palsy Lower urinary tract symptoms Intraoperative neurophysiological monitoring Bladder dysfunction |
| title | Effect of selective dorsal rhizotomy on bladder dysfunction in children with spastic cerebral palsy |
| title_full | Effect of selective dorsal rhizotomy on bladder dysfunction in children with spastic cerebral palsy |
| title_fullStr | Effect of selective dorsal rhizotomy on bladder dysfunction in children with spastic cerebral palsy |
| title_full_unstemmed | Effect of selective dorsal rhizotomy on bladder dysfunction in children with spastic cerebral palsy |
| title_short | Effect of selective dorsal rhizotomy on bladder dysfunction in children with spastic cerebral palsy |
| title_sort | effect of selective dorsal rhizotomy on bladder dysfunction in children with spastic cerebral palsy |
| topic | Selective dorsal rhizotomy Spastic cerebral palsy Lower urinary tract symptoms Intraoperative neurophysiological monitoring Bladder dysfunction |
| url | https://doi.org/10.1038/s41598-024-81512-w |
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