Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation

Artemisinin-resistant Plasmodium falciparum Kelch13 mutant proteins display reduced heme-binding affinity and decreased artemisinin activation

Abstract The potency of frontline antimalarial drug artemisinin (ART) derivatives is triggered by heme-induced cleavage of the endoperoxide bond to form reactive heme-ART alkoxy radicals and covalent heme-ART adducts, which are highly toxic to the parasite. ART-resistant (ART-R) parasites with mutat...

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Main Authors: Abdur Rahman, Sabahat Tamseel, Smritikana Dutta, Nawaal Khan, Mohammad Faaiz, Harshita Rastogi, Jyoti Rani Nath, Kasturi Haldar, Pramit Chowdhury, Ashish, Souvik Bhattacharjee
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07178-2
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