Coronary artery wall contrast enhancement imaging impact on disease activity assessment in IgG4-RD: a direct marker of coronary involvement
Background: Coronary artery wall contrast enhancement (CE) has been applied to non-invasive visualization of changes to the coronary artery wall in systemic lupus erythematosus (SLE). This study investigated the feasibility of quantifying CE to detect coronary involvement in IgG4-related disease (Ig...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1097664724010743 |
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| author | Yaqi Du Shuang Ding Ce Li Yun Bai Xinrui Wang Debiao Li Yibin Xie Guoguang Fan Lian-Ming Wu Guan Wang |
| author_facet | Yaqi Du Shuang Ding Ce Li Yun Bai Xinrui Wang Debiao Li Yibin Xie Guoguang Fan Lian-Ming Wu Guan Wang |
| author_sort | Yaqi Du |
| collection | DOAJ |
| description | Background: Coronary artery wall contrast enhancement (CE) has been applied to non-invasive visualization of changes to the coronary artery wall in systemic lupus erythematosus (SLE). This study investigated the feasibility of quantifying CE to detect coronary involvement in IgG4-related disease (IgG4-RD), as well as the influence on disease activity assessment. Methods: A total of 93 subjects (31 IgG4-RD; 29 SLE; 33 controls) were recruited in the study. Coronary artery wall imaging was performed in a 3.0 T MRI scanner. Serological markers and IgG4-RD Responder Index (IgG4-RD-RI) scores were collected for correlation analysis. Results: Coronary wall CE was observed in 29 (94 %) IgG4-RD patients and 22 (76 %) SLE patients. Contrast-to-noise ratio (CNR) and total CE area were significantly higher in patient groups compared to controls (CNR: 6.1 ± 2.7 [IgG4-RD] v. 4.2 ± 2.3 [SLE] v. 1.9 ± 1.5 [control], P < 0.001; Total CE area: 3.0 [3.0–6.6] v. 1.7 [1.5–2.6] v. 0.3 [0.3–0.9], P < 0.001). In the IgG4-RD group, CNR and total CE area were correlated with the RI (CNR: r = 0.55, P = 0.002; total CE area: r = 0.39, P = 0.031). RI´ scored considering coronary involvement by CE, differed significantly from RI scored without consideration of CE (RI v. RI´: 15 ± 6 v. 16 ± 6, P < 0.001). Conclusions: Visualization and quantification of CMR coronary CE by CNR and total CE area could be utilized to detect subclinical and clinical coronary wall involvement, which is prevalent in IgG4-RD. The potential inclusion of small and medium-sized vessel involvements in the assessment of disease activity in IgG4-RD is worthy of further investigation. |
| format | Article |
| id | doaj-art-7aad11d6cd404a3fbfbf8ced65534048 |
| institution | Kabale University |
| issn | 1097-6647 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj-art-7aad11d6cd404a3fbfbf8ced655340482024-12-16T05:34:37ZengElsevierJournal of Cardiovascular Magnetic Resonance1097-66472024-01-01262101047Coronary artery wall contrast enhancement imaging impact on disease activity assessment in IgG4-RD: a direct marker of coronary involvementYaqi Du0Shuang Ding1Ce Li2Yun Bai3Xinrui Wang4Debiao Li5Yibin Xie6Guoguang Fan7Lian-Ming Wu8Guan Wang9Department of Radiology, the First Hospital of China Medical University, Shenyang, ChinaDepartment of rheumatology and immunology, the First Hospital of China Medical University, Shenyang, ChinaDepartment of Medical Oncology, the First Hospital of China Medical University, Shenyang, ChinaDepartment of Radiology, the First Hospital of China Medical University, Shenyang, ChinaDepartment of Radiology, the First Hospital of China Medical University, Shenyang, ChinaBiomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CaliforniaBiomedical Imaging Research Institute, Cedars Sinai Medical Center, Los Angeles, CaliforniaDepartment of Radiology, the First Hospital of China Medical University, Shenyang, China; Correspondence to: Department of Radiology, the First Hospital of China Medical University, No.155, North Nanjing Street, Shenyang, 110001 Liaoning, China.Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Correspondence to: Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160 PuJian Road, Shanghai 200127, P.R. China.Department of Radiology, the First Hospital of China Medical University, Shenyang, China; Correspondence to: Department of Radiology, the First Hospital of China Medical University, No.155, North Nanjing Street, Shenyang, 110001 Liaoning, China.Background: Coronary artery wall contrast enhancement (CE) has been applied to non-invasive visualization of changes to the coronary artery wall in systemic lupus erythematosus (SLE). This study investigated the feasibility of quantifying CE to detect coronary involvement in IgG4-related disease (IgG4-RD), as well as the influence on disease activity assessment. Methods: A total of 93 subjects (31 IgG4-RD; 29 SLE; 33 controls) were recruited in the study. Coronary artery wall imaging was performed in a 3.0 T MRI scanner. Serological markers and IgG4-RD Responder Index (IgG4-RD-RI) scores were collected for correlation analysis. Results: Coronary wall CE was observed in 29 (94 %) IgG4-RD patients and 22 (76 %) SLE patients. Contrast-to-noise ratio (CNR) and total CE area were significantly higher in patient groups compared to controls (CNR: 6.1 ± 2.7 [IgG4-RD] v. 4.2 ± 2.3 [SLE] v. 1.9 ± 1.5 [control], P < 0.001; Total CE area: 3.0 [3.0–6.6] v. 1.7 [1.5–2.6] v. 0.3 [0.3–0.9], P < 0.001). In the IgG4-RD group, CNR and total CE area were correlated with the RI (CNR: r = 0.55, P = 0.002; total CE area: r = 0.39, P = 0.031). RI´ scored considering coronary involvement by CE, differed significantly from RI scored without consideration of CE (RI v. RI´: 15 ± 6 v. 16 ± 6, P < 0.001). Conclusions: Visualization and quantification of CMR coronary CE by CNR and total CE area could be utilized to detect subclinical and clinical coronary wall involvement, which is prevalent in IgG4-RD. The potential inclusion of small and medium-sized vessel involvements in the assessment of disease activity in IgG4-RD is worthy of further investigation.http://www.sciencedirect.com/science/article/pii/S1097664724010743IgG4-related cardiovascular diseaseCardiovascular magnetic resonanceCoronary wall contrast enhancementIgG4-RD responder index |
| spellingShingle | Yaqi Du Shuang Ding Ce Li Yun Bai Xinrui Wang Debiao Li Yibin Xie Guoguang Fan Lian-Ming Wu Guan Wang Coronary artery wall contrast enhancement imaging impact on disease activity assessment in IgG4-RD: a direct marker of coronary involvement Journal of Cardiovascular Magnetic Resonance IgG4-related cardiovascular disease Cardiovascular magnetic resonance Coronary wall contrast enhancement IgG4-RD responder index |
| title | Coronary artery wall contrast enhancement imaging impact on disease activity assessment in IgG4-RD: a direct marker of coronary involvement |
| title_full | Coronary artery wall contrast enhancement imaging impact on disease activity assessment in IgG4-RD: a direct marker of coronary involvement |
| title_fullStr | Coronary artery wall contrast enhancement imaging impact on disease activity assessment in IgG4-RD: a direct marker of coronary involvement |
| title_full_unstemmed | Coronary artery wall contrast enhancement imaging impact on disease activity assessment in IgG4-RD: a direct marker of coronary involvement |
| title_short | Coronary artery wall contrast enhancement imaging impact on disease activity assessment in IgG4-RD: a direct marker of coronary involvement |
| title_sort | coronary artery wall contrast enhancement imaging impact on disease activity assessment in igg4 rd a direct marker of coronary involvement |
| topic | IgG4-related cardiovascular disease Cardiovascular magnetic resonance Coronary wall contrast enhancement IgG4-RD responder index |
| url | http://www.sciencedirect.com/science/article/pii/S1097664724010743 |
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