A call to action to address critical flaws and bias in laboratory animal experiments and preclinical research

Abstract During the design of hypothesis-driven, comparative laboratory animal experiments, investigators must control for cage effects, ensure full blinding and full randomization while adhering to established experimental designs, notably variations of the Completely Randomized Design and the Rand...

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Main Authors: Hugh G. G. Townsend, Klaus Osterrieder, Murray D. Jelinski, Douglas W. Morck, Cheryl L. Waldner, William R. Cox, Volker Gerdts, Andrew A. Potter, Lorne A. Babiuk, James C. Cross
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-15935-4
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author Hugh G. G. Townsend
Klaus Osterrieder
Murray D. Jelinski
Douglas W. Morck
Cheryl L. Waldner
William R. Cox
Volker Gerdts
Andrew A. Potter
Lorne A. Babiuk
James C. Cross
author_facet Hugh G. G. Townsend
Klaus Osterrieder
Murray D. Jelinski
Douglas W. Morck
Cheryl L. Waldner
William R. Cox
Volker Gerdts
Andrew A. Potter
Lorne A. Babiuk
James C. Cross
author_sort Hugh G. G. Townsend
collection DOAJ
description Abstract During the design of hypothesis-driven, comparative laboratory animal experiments, investigators must control for cage effects, ensure full blinding and full randomization while adhering to established experimental designs, notably variations of the Completely Randomized Design and the Randomized Block Designs. Failure to meet these criteria introduces partial or complete confounding by multiple known and unknown variables, resulting in biased outcome measures and rendering valid statistical analysis impossible. Our analysis of a stratified, random sample of comparative laboratory animal experiments conducted in North America and Europe and published in 2022, shows that as few as 0–2.5% utilized valid, unbiased experimental designs. The failure of investigators to adopt valid, unbiased study designs undermines scientific rigour, squanders resources and animal lives, and impedes the reliable translation of preclinical research findings to human and veterinary medicine. We propose practical, achievable solutions focused on enhancing the rigour and validity of study designs. This includes developing a specialized group of scientists with expertise in the design of laboratory animal experiments and data analysis, to ensure future studies are conducted with the highest scientific standards.
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institution Kabale University
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publishDate 2025-08-01
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series Scientific Reports
spelling doaj-art-7a8cc83c15d54f8a927e7a01a25b1a2a2025-08-24T11:26:10ZengNature PortfolioScientific Reports2045-23222025-08-0115111110.1038/s41598-025-15935-4A call to action to address critical flaws and bias in laboratory animal experiments and preclinical researchHugh G. G. Townsend0Klaus Osterrieder1Murray D. Jelinski2Douglas W. Morck3Cheryl L. Waldner4William R. Cox5Volker Gerdts6Andrew A. Potter7Lorne A. Babiuk8James C. Cross9Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine (Emeritus) and Vaccine and Infectious Disease Organization (Retired), University of SaskatchewanUniversity of Veterinary Medicine Hannover, FoundationDepartment of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of SaskatchewanDepartment of Biological Sciences, Faculty of Science, University of CalgaryDepartment of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of SaskatchewanAmphoraxe Life SciencesVaccine and Infectious Disease Organization and Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of SaskatchewanDepartment of Veterinary Microbiology (Emeritus), Western College of Veterinary Medicine and Vaccine and Infectious Disease Organization (Retired), University of SaskatchewanDepartment of Veterinary Microbiology (Emeritus), Western College of Veterinary Medicine and Vaccine and Infectious Disease Organization (Retired), University of SaskatchewanFaculty of Veterinary Medicine (Emeritus), University of CalgaryAbstract During the design of hypothesis-driven, comparative laboratory animal experiments, investigators must control for cage effects, ensure full blinding and full randomization while adhering to established experimental designs, notably variations of the Completely Randomized Design and the Randomized Block Designs. Failure to meet these criteria introduces partial or complete confounding by multiple known and unknown variables, resulting in biased outcome measures and rendering valid statistical analysis impossible. Our analysis of a stratified, random sample of comparative laboratory animal experiments conducted in North America and Europe and published in 2022, shows that as few as 0–2.5% utilized valid, unbiased experimental designs. The failure of investigators to adopt valid, unbiased study designs undermines scientific rigour, squanders resources and animal lives, and impedes the reliable translation of preclinical research findings to human and veterinary medicine. We propose practical, achievable solutions focused on enhancing the rigour and validity of study designs. This includes developing a specialized group of scientists with expertise in the design of laboratory animal experiments and data analysis, to ensure future studies are conducted with the highest scientific standards.https://doi.org/10.1038/s41598-025-15935-4
spellingShingle Hugh G. G. Townsend
Klaus Osterrieder
Murray D. Jelinski
Douglas W. Morck
Cheryl L. Waldner
William R. Cox
Volker Gerdts
Andrew A. Potter
Lorne A. Babiuk
James C. Cross
A call to action to address critical flaws and bias in laboratory animal experiments and preclinical research
Scientific Reports
title A call to action to address critical flaws and bias in laboratory animal experiments and preclinical research
title_full A call to action to address critical flaws and bias in laboratory animal experiments and preclinical research
title_fullStr A call to action to address critical flaws and bias in laboratory animal experiments and preclinical research
title_full_unstemmed A call to action to address critical flaws and bias in laboratory animal experiments and preclinical research
title_short A call to action to address critical flaws and bias in laboratory animal experiments and preclinical research
title_sort call to action to address critical flaws and bias in laboratory animal experiments and preclinical research
url https://doi.org/10.1038/s41598-025-15935-4
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