Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate
Abstract Membrane channels play an important role in auditory processes. Connexins and pannexins are membrane channels that exist in the cochlea. Connexin26 and connexin30 have been previously shown to be differentially expressed in the developing cochlea of primates in a species-specific manner. Ho...
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-15685-3 |
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| author | Makoto Hosoya Satoshi Suda Masafumi Ueno Marie N. Shimanuki Takanori Nishiyama Naoki Oishi Hiroyuki Ozawa |
| author_facet | Makoto Hosoya Satoshi Suda Masafumi Ueno Marie N. Shimanuki Takanori Nishiyama Naoki Oishi Hiroyuki Ozawa |
| author_sort | Makoto Hosoya |
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| description | Abstract Membrane channels play an important role in auditory processes. Connexins and pannexins are membrane channels that exist in the cochlea. Connexin26 and connexin30 have been previously shown to be differentially expressed in the developing cochlea of primates in a species-specific manner. However, whether other connexins and pannexins are also expressed in the developing primate cochlea has not been investigated. In this study, we sought to examine the expression patterns of connexin43, connexin31, and pannexin1 during cochlear development in a primate animal model, the common marmoset, to determine the differences observed between the marmoset and existing rodent models. Our observations revealed both interspecies differences in the expression patterns of these genes and similarities between rodents and primates. These results indicate that the spatiotemporal patterns of connexin and pannexin expression are complex and differ between rodents and primates. They also highlight the importance of carefully observing differences in developmental changes in connexins and pannexins between humans and rodents. |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-7a88d9a1037f4931b1e5a7b954b4789c2025-08-20T03:45:57ZengNature PortfolioScientific Reports2045-23222025-08-0115111110.1038/s41598-025-15685-3Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primateMakoto Hosoya0Satoshi Suda1Masafumi Ueno2Marie N. Shimanuki3Takanori Nishiyama4Naoki Oishi5Hiroyuki Ozawa6Department of Otorhinolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of MedicineDepartment of Otorhinolaryngology, Head and Neck Surgery, Keio University School of MedicineAbstract Membrane channels play an important role in auditory processes. Connexins and pannexins are membrane channels that exist in the cochlea. Connexin26 and connexin30 have been previously shown to be differentially expressed in the developing cochlea of primates in a species-specific manner. However, whether other connexins and pannexins are also expressed in the developing primate cochlea has not been investigated. In this study, we sought to examine the expression patterns of connexin43, connexin31, and pannexin1 during cochlear development in a primate animal model, the common marmoset, to determine the differences observed between the marmoset and existing rodent models. Our observations revealed both interspecies differences in the expression patterns of these genes and similarities between rodents and primates. These results indicate that the spatiotemporal patterns of connexin and pannexin expression are complex and differ between rodents and primates. They also highlight the importance of carefully observing differences in developmental changes in connexins and pannexins between humans and rodents.https://doi.org/10.1038/s41598-025-15685-3Common marmosetCochleaDevelopmentConnexinPannexin |
| spellingShingle | Makoto Hosoya Satoshi Suda Masafumi Ueno Marie N. Shimanuki Takanori Nishiyama Naoki Oishi Hiroyuki Ozawa Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate Scientific Reports Common marmoset Cochlea Development Connexin Pannexin |
| title | Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate |
| title_full | Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate |
| title_fullStr | Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate |
| title_full_unstemmed | Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate |
| title_short | Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate |
| title_sort | distinct connexin43 connexin31 and pannexin1 expression patterns in the cochlea of a non human primate |
| topic | Common marmoset Cochlea Development Connexin Pannexin |
| url | https://doi.org/10.1038/s41598-025-15685-3 |
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