Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy

Altered cytoskeleton dynamics in patient-derived iPSC-based model of PCDH19 clustering epilepsy

Protocadherin 19 (PCDH19) is an adhesion molecule involved in cell-cell interaction whose mutations cause a drug-resistant form of epilepsy, named PCDH19-Clustering Epilepsy (PCDH19-CE, MIM 300088). The mechanism by which altered PCDH19 function drive pathogenesis is not yet fully understood. Our pr...

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Bibliographic Details
Main Authors:	Rossella Borghi, Stefania Petrini, Valentina Apollonio, Marina Trivisano, Nicola Specchio, Sandra Moreno, Enrico Bertini, Marco Tartaglia, Claudia Compagnucci
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	PCDH19 epilepsy IPSC-derived neurons microfilaments microtubules cytoskeletal dynamics
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1518533/full
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