Analytical and clinical performance of eight Simoa® and Lumipulse® assays for automated measurement of plasma p-tau181 and p-tau217

Analytical and clinical performance of eight Simoa® and Lumipulse® assays for automated measurement of plasma p-tau181 and p-tau217

Abstract Background Among the Alzheimer’s disease (AD) biomarkers measured in blood, phosphorylated forms of tau (p-tau) have been shown to exhibit a particularly high diagnostic potential. Here, we performed a comprehensive method comparison study, followed by evaluation of the diagnostic performan...

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Main Authors: Anna L. Wojdała, Jeroen Vanbrabant, Sherif Bayoumy, Daniel Antwi-Berko, Nathalie Le Bastard, Wiesje M. van der Flier, Andreas Jeromin, Charlotte Lambrechts, Maxime Van Loo, Manu Vandijck, Erik Stoops, Inge M. W. Verberk, Charlotte E. Teunissen
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Blood
Plasma
Biomarkers
Immunoassay
P-tau181
Online Access:https://doi.org/10.1186/s13195-024-01630-5
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