Biochemical and structural characterization of a reactive intermediate deaminase A homolog from Streptococcus sanguinis

Biochemical and structural characterization of a reactive intermediate deaminase A homolog from Streptococcus sanguinis

Abstract 2-Aminoacrylate (2AA) is a short-lived enamine generated as a catalytic intermediate in the dehydration of serine by serine/threonine dehydratase enzymes. 2AA is a metabolic stressor capable of inactivating important pyridoxal phosphate dependent enzymes in a cell. Detoxification of 2AA in...

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Main Authors: Alexa B. Benedict, Adreana I. Aquino, Brandi A. Buckner, Swarmistha Devi Aribam, Chhandosee Ganguly, Leonard M. Thomas, Philip Bourne, Rakhi Rajan, Diana M. Downs, Vijayakumar Somalinga
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
RidA
Enamine deaminase
Streptococcus sanguinis
2-Amino acrylate
Metabolic stress
Online Access:https://doi.org/10.1038/s41598-025-05264-x
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https://doi.org/10.1038/s41598-025-05264-x

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