The inhibitory effect of type V transforming growth factor-β receptor antagonist on the proliferation of keloid fibroblasts by suppressing insulin-like growth factor-binding protein 3-interleukin-6 signaling

The inhibitory effect of type V transforming growth factor-β receptor antagonist on the proliferation of keloid fibroblasts by suppressing insulin-like growth factor-binding protein 3-interleukin-6 signaling

Background: Hyperplasia of fibroblasts is critical in keloid pathogenesis. Insulin-like growth factor-binding protein 3 (IGFBP3) is an important factor in the regulation of cell growth and type V transforming growth factor-β receptor (TβR-V) is a specific receptor of IGFBP3. However, the role of IGF...

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Bibliographic Details
Main Authors: Boya Zhou, Xunxun Lin, Lingling Xia, Zhen Gao, Meihua Di, Xiaoli Wu, Wenbo Wang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-11-01
Series:Dermatologica Sinica
Subjects:
cell proliferation
insulin-like growth factor-binding protein 3
interleukin-6
keloid fibroblasts
type v transforming growth factor-β
receptor antagonist
Online Access:https://journals.lww.com/10.4103/ds.DS-D-24-00052
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