RIPK4 Downregulation Reduces ABCG2 Expression, Increasing BRAF-Mutated Melanoma Cell Susceptibility to Cisplatin- and Doxorubicin-Induced Apoptosis

RIPK4 Downregulation Reduces ABCG2 Expression, Increasing BRAF-Mutated Melanoma Cell Susceptibility to Cisplatin- and Doxorubicin-Induced Apoptosis

Melanoma cells remain resistant to chemotherapy with cisplatin (CisPt) and doxorubicin (DOX). The abnormal expression of Receptor-Interacting Protein Kinase 4 (RIPK4) in certain melanomas contributes to tumour growth through the NFκB and Wnt/β-catenin signalling pathways, which are known to regulate...

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Bibliographic Details
Main Authors: Bartlomiej Olajossy, Norbert Wronski, Ewelina Madej, Joanna Komperda, Małgorzata Szczygieł, Agnieszka Wolnicka-Glubisz
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomolecules
Subjects:
MPR
melanoma
RIPK4
cyclosporin A
cisplatin
doxorubicin
Online Access:https://www.mdpi.com/2218-273X/14/12/1573
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